Cited 29 times in
Microinjection of ghrelin in the nucleus accumbens core enhances locomotor activity induced by cocaine
DC Field | Value | Language |
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dc.contributor.author | 김정훈 | - |
dc.contributor.author | 김화영 | - |
dc.contributor.author | 이정원 | - |
dc.contributor.author | 장주경 | - |
dc.date.accessioned | 2014-12-18T08:39:48Z | - |
dc.date.available | 2014-12-18T08:39:48Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0166-4328 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86724 | - |
dc.description.abstract | Ghrelin has a regulatory role not only in the rewarding aspect for feeding but also in drug addiction by interaction with mesolimbic dopaminergic pathways in the brain. Previously it has been shown that systemic ghrelin enhances cocaine-induced hyper-locomotor activity. However, it has not been determined yet what effects ghrelin may produce on cocaine-induced locomotor behavior when microinjected into the nucleus accumbens core, where cocaine actually produces its locomotor activating effects. In the present study, when rats were administered cocaine (15 mg/kg, i.p.) following a bilateral microinjection of ghrelin (0.1 or 0.5 μg/side) into the NAcc core, their locomotor activity was significantly enhanced, while these effects were inhibited by co-microinjection of ghrelin receptor antagonist (0.5 μg/side) into this site. When ghrelin alone microinjected, basal locomotor activity was unchanged. These results expand previous similar findings obtained by systemic ghrelin to more specific neuronal site, the nucleus accumbens core, and further suggest that it may work in this site to positively contribute to the expression of locomotor sensitization. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | BEHAVIOURAL BRAIN RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Behavior, Animal/drug effects | - |
dc.subject.MESH | Cocaine/administration & dosage | - |
dc.subject.MESH | Cocaine/pharmacology* | - |
dc.subject.MESH | Dopamine/metabolism | - |
dc.subject.MESH | Ghrelin/pharmacology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microinjections*/methods | - |
dc.subject.MESH | Motor Activity/drug effects* | - |
dc.subject.MESH | Nucleus Accumbens/drug effects* | - |
dc.subject.MESH | Nucleus Accumbens/metabolism | - |
dc.subject.MESH | Nucleus Accumbens/physiology | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Substance-Related Disorders/metabolism | - |
dc.title | Microinjection of ghrelin in the nucleus accumbens core enhances locomotor activity induced by cocaine | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | Ju Kyong Jang | - |
dc.contributor.googleauthor | Wha Young Kim | - |
dc.contributor.googleauthor | Bo Ram Cho | - |
dc.contributor.googleauthor | Jung Won Lee | - |
dc.contributor.googleauthor | Jeong-Hoon Kim | - |
dc.identifier.doi | 10.1016/j.bbr.2013.03.049 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00908 | - |
dc.contributor.localId | A01198 | - |
dc.contributor.localId | A03118 | - |
dc.contributor.localId | A03471 | - |
dc.relation.journalcode | J00275 | - |
dc.identifier.eissn | 1872-7549 | - |
dc.identifier.pmid | 23578756 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0166432813001915 | - |
dc.subject.keyword | Ghrelin | - |
dc.subject.keyword | Nucleus accumbens core | - |
dc.subject.keyword | Cocaine | - |
dc.subject.keyword | Locomotor activity | - |
dc.contributor.alternativeName | Kim, Jeong Hoon | - |
dc.contributor.alternativeName | Kim, Wha Young | - |
dc.contributor.alternativeName | Lee, Jung Won | - |
dc.contributor.alternativeName | Jang, Ju Kyong | - |
dc.contributor.affiliatedAuthor | Kim, Jeong Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Wha Young | - |
dc.contributor.affiliatedAuthor | Lee, Jung Won | - |
dc.contributor.affiliatedAuthor | Jang, Ju Kyong | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 248 | - |
dc.citation.startPage | 7 | - |
dc.citation.endPage | 11 | - |
dc.identifier.bibliographicCitation | BEHAVIOURAL BRAIN RESEARCH, Vol.248 : 7-11, 2013 | - |
dc.identifier.rimsid | 29166 | - |
dc.type.rims | ART | - |
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