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Xanthorrhizol induces apoptotic cell death through molecular cross talks between mitochondria-dependent and death receptor-mediated signaling in human promyelocytic leukemia cells

Authors
 Hyun-Jeong Kim  ;  Won-Yoon Chung  ;  Jae-Kwan Hwang  ;  Kwang-Kyun Park 
Citation
 Cancer Prevention Research, Vol.18(1) : 41-47, 2013 
Journal Title
 Cancer Prevention Research 
ISSN
 1229-0165 
Issue Date
2013
Abstract
Xanthorrhizol, isolated from Curcuma xanthorrhiza, has been shown to induce cell cycle arrest and apoptotic cell death by mainly mitochondrial-dependent signaling pathway in several human cancer cells. We investigated whether xanthorrhizol could apoptosis in HL-60 human promyelocytic leukemia cells. Xanthorrhizol treatment inhibited cell viability and induced apoptotic cell death. The levels of procaspase-3, -8 and -9 were reduced and the cleavage of full length PARP was clearly observed in xanthorrhizol-treated cells. Xanthorrhizol treatment did not affect Bcl-2 protein level but increased Bax protein level, resulting in the diminished Bcl-2/Bax ratio. The levels of cleaved Bid, Fas death receptor and p53, not FasL, were also increased by xanthorrhizol treatment. In conclusion, molecular cross talks between the intrinsic and extrinsic apoptotic pathway via Bid may play an important role for induction of apoptosis in xanthorrhizol-treated HL-60 cells. Therefore, xanthorrhizol has the chemorpeventive and anti-cancer potential against human promyelocytic leukemia cells
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86722
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실)
Yonsei Authors
김현정(Kim, Hyun Jeong) ; 박광균(Park, Kwang Kyun) ; 정원윤(Chung, Won Yoon)
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