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Variants of the Adiponectin Gene and Diabetic Microvascular Complications in Patients with Type 2 Diabetes

DC Field Value Language
dc.contributor.author강은석-
dc.contributor.author권오빈-
dc.contributor.author김범석-
dc.contributor.author안철우-
dc.contributor.author왕혜진-
dc.contributor.author이병완-
dc.contributor.author이현철-
dc.contributor.author차봉수-
dc.contributor.author최은영-
dc.contributor.author김광준-
dc.date.accessioned2014-12-18T08:39:42Z-
dc.date.available2014-12-18T08:39:42Z-
dc.date.issued2013-
dc.identifier.issn0026-0495-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86721-
dc.description.abstractOBJECTIVE: The aim of this study was to examine the association between common polymorphisms of the adiponectin gene (ADIPOQ) and microvascular complications in patients with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS: Rs2241766 and rs1501299 of ADIPOQ were genotyped in 708 patients with T2DM. Fundus photography, nerve conducting velocity, and urine analysis were performed to check for the presence of microvascular complications including diabetic nephropathy, retinopathy and neuropathy. RESULTS: The prevalence of diabetic nephropathy tended to be different according to rs2241766 genotype (p=0.057) and the GG genotype of rs2241766 was associated with diabetic nephropathy [urine albumin/creatinine ratio (UACR) greater than 30 mg/g] after adjusting for age, sex, body mass index, duration of diabetes, HDL-cholesterol, smoking status, and blood pressure (odds ratio=1.96; 95% confidence interval=1.01-3.82, p=0.049). Also, the G allele of rs2241766 demonstrated a trend to be associated with an increase in UACR (p=0.087). Rs2241766 genotype was not associated with diabetic retinopathy (p=0.955) and neuropathy (p=0.104) or any diabetic microvascular complications (p=0.104). There was no significant association between the rs1501299 genotype of ADIPOQ and the prevalence of diabetic retinopathy and neuropathy or any diabetic microvascular complications even after adjustment. CONCLUSION: These data suggest that the GG genotype at rs2241766 is implicated in the pathogenesis of risk for diabetic nephropathy defined as UACR greater than 30 mg/day in patients with T2DM.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfMETABOLISM-CLINICAL AND EXPERIMENTAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdiponectin/genetics*-
dc.subject.MESHAged-
dc.subject.MESHDiabetes Mellitus, Type 2/complications*-
dc.subject.MESHDiabetes Mellitus, Type 2/epidemiology-
dc.subject.MESHDiabetes Mellitus, Type 2/genetics*-
dc.subject.MESHDiabetic Angiopathies/epidemiology-
dc.subject.MESHDiabetic Angiopathies/genetics*-
dc.subject.MESHFemale-
dc.subject.MESHGenetic Predisposition to Disease-
dc.subject.MESHGenotype-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMicrovessels/pathology-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPolymorphism, Single Nucleotide/physiology-
dc.subject.MESHPrevalence-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.titleVariants of the Adiponectin Gene and Diabetic Microvascular Complications in Patients with Type 2 Diabetes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorEun Yeong Choe-
dc.contributor.googleauthorHye Jin Wang-
dc.contributor.googleauthorObin Kwon-
dc.contributor.googleauthorKwang Joon Kim-
dc.contributor.googleauthorBum Seok Kim-
dc.contributor.googleauthorByung-Wan Lee-
dc.contributor.googleauthorChul Woo Ahn-
dc.contributor.googleauthorBong Soo Cha-
dc.contributor.googleauthorHyun Chul Lee-
dc.contributor.googleauthorEun Seok Kang-
dc.contributor.googleauthorChristos S. Mantzoros-
dc.identifier.doi10.1016/j.metabol.2012.11.005-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00068-
dc.contributor.localIdA00234-
dc.contributor.localIdA00488-
dc.contributor.localIdA02270-
dc.contributor.localIdA02422-
dc.contributor.localIdA02796-
dc.contributor.localIdA03301-
dc.contributor.localIdA03996-
dc.contributor.localIdA04153-
dc.contributor.localIdA00317-
dc.relation.journalcodeJ02223-
dc.identifier.eissn1532-8600-
dc.identifier.pmid23260797-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0026049512004398-
dc.subject.keywordAdiponectin-
dc.subject.keywordGene-
dc.subject.keywordType 2 diabetes mellitus-
dc.subject.keywordMicrovascular complications-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.alternativeNameKwon, O Bin-
dc.contributor.alternativeNameKim, Beom Seok-
dc.contributor.alternativeNameAhn, Chul Woo-
dc.contributor.alternativeNameWang, Hye Jin-
dc.contributor.alternativeNameLee, Byung Wan-
dc.contributor.alternativeNameLee, Hyun Chul-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.alternativeNameChoe, Eun Yeong-
dc.contributor.affiliatedAuthorKang, Eun Seok-
dc.contributor.affiliatedAuthorKwon, O Bin-
dc.contributor.affiliatedAuthorKim, Beom Seok-
dc.contributor.affiliatedAuthorAhn, Chul Woo-
dc.contributor.affiliatedAuthorWang, Hye Jin-
dc.contributor.affiliatedAuthorLee, Byung Wan-
dc.contributor.affiliatedAuthorLee, Hyun Chul-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.contributor.affiliatedAuthorChoe, Eun Yeong-
dc.contributor.affiliatedAuthorKim, Kwang Joon-
dc.rights.accessRightsnot free-
dc.citation.volume62-
dc.citation.number5-
dc.citation.startPage677-
dc.citation.endPage685-
dc.identifier.bibliographicCitationMETABOLISM-CLINICAL AND EXPERIMENTAL, Vol.62(5) : 677-685, 2013-
dc.identifier.rimsid29163-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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