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Functional connectivity-based identification of subdivisions of the basal ganglia and thalamus using multilevel independent component analysis of resting state fMRI

Authors
 Dae-Jin Kim  ;  Bumhee Park  ;  Hae-Jeong Park 
Citation
 Human Brain Mapping, Vol.34(6) : 1371-1385, 2013 
Journal Title
 Human Brain Mapping 
ISSN
 1065-9471 
Issue Date
2013
Abstract
This study aimed to identify subunits of the basal ganglia and thalamus and to investigate the functional connectivity among these anatomically segregated subdivisions and the cerebral cortex in healthy subjects. For this purpose, we introduced multilevel independent component analysis (ICA) of the resting-state functional magnetic resonance imaging (fMRI). After applying ICA to the whole brain gray matter, we applied second-level ICA restrictively to the basal ganglia and the thalamus area to identify discrete functional subunits of those regions. As a result, the basal ganglia and the thalamus were parcelled into 31 functional subdivisions according to their temporal activity patterns. The extracted parcels showed functional network connectivity between hemispheres, between subdivisions of the basal ganglia and thalamus, and between the extracted subdivisions and cerebral functional components. Grossly, these findings correspond to cortico-striato-thalamo-cortical circuits in the brain. This study also showed the utility of multilevel ICA of resting state fMRI in brain network research.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86679
DOI
10.1002/hbm.21517
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터)
Yonsei Authors
김대진(Kim, Dae Jin) ; 박범희(Park, Bum Hee) ; 박해정(Park, Hae Jeong)
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Full Text
http://onlinelibrary.wiley.com/doi/10.1002/hbm.21517/abstract
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