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Genome-wide association analyses in east Asians identify new susceptibility loci for colorectal cancer

Authors
 Wei-Hua Jia  ;  Ben Zhang  ;  Keitaro Matsuo  ;  Aesun Shin  ;  Yong-Bing Xiang  ;  Sun Ha Jee  ;  Dong-Hyun Kim  ;  Zefang Ren  ;  Qiuyin Cai  ;  Jirong Long  ;  Jiajun Shi  ;  Wanqing Wen  ;  Gong Yang  ;  Ryan J Delahanty  ;  Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO)  ;  Colon Cancer Family Registry (CCFR)  ;  Bu-Tian Ji  ;  Zhi-Zhong Pan  ;  Fumihiko Matsuda  ;  Yu-Tang Gao  ;  Jae Hwan Oh  ;  Yoon-Ok Ahn  ;  Eun Jung Park  ;  Hong-Lan Li  ;  Ji Won Park  ;  Jaeseong Jo  ;  Jin-Young Jeong  ;  Satoyo Hosono  ;  Graham Casey  ;  Ulrike Peters  ;  Xiao-Ou Shu  ;  Yi-Xin Zeng  ;  Wei Zheng 
Citation
 Nature Genetics, Vol.45(2) : 191-196, 2013 
Journal Title
 Nature Genetics 
ISSN
 1061-4036 
Issue Date
2013
Abstract
To identify new genetic factors for colorectal cancer (CRC), we conducted a genome-wide association study in east Asians. By analyzing genome-wide data in 2,098 cases and 5,749 controls, we selected 64 promising SNPs for replication in an independent set of samples, including up to 5,358 cases and 5,922 controls. We identified four SNPs with association P values of 8.58 × 10(-7) to 3.77 × 10(-10) in the combined analysis of all east Asian samples. Three of the four were replicated in a study conducted in 26,060 individuals of European descent, with combined P values of 1.22 × 10(-10) for rs647161 (5q31.1), 6.64 × 10(-9) for rs2423279 (20p12.3) and 3.06 × 10(-8) for rs10774214 (12p13.32 near the CCND2 gene), derived from meta-analysis of data from both east Asian and European-ancestry populations. This study identified three new CRC susceptibility loci and provides additional insight into the genetics and biology of CRC.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86534
DOI
10.1038/ng.2505
Appears in Collections:
1. Journal Papers (연구논문) > 4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원)
Yonsei Authors
지선하(Jee, Sun Ha)
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Full Text
http://www.nature.com/ng/journal/v45/n2/full/ng.2505.html
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