5 196

Cited 125 times in

Genome-wide association analyses in east Asians identify new susceptibility loci for colorectal cancer

DC FieldValueLanguage
dc.contributor.author지선하-
dc.date.accessioned2014-12-18T08:33:35Z-
dc.date.available2014-12-18T08:33:35Z-
dc.date.issued2013-
dc.identifier.issn1061-4036-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86534-
dc.description.abstractTo identify new genetic factors for colorectal cancer (CRC), we conducted a genome-wide association study in east Asians. By analyzing genome-wide data in 2,098 cases and 5,749 controls, we selected 64 promising SNPs for replication in an independent set of samples, including up to 5,358 cases and 5,922 controls. We identified four SNPs with association P values of 8.58 × 10(-7) to 3.77 × 10(-10) in the combined analysis of all east Asian samples. Three of the four were replicated in a study conducted in 26,060 individuals of European descent, with combined P values of 1.22 × 10(-10) for rs647161 (5q31.1), 6.64 × 10(-9) for rs2423279 (20p12.3) and 3.06 × 10(-8) for rs10774214 (12p13.32 near the CCND2 gene), derived from meta-analysis of data from both east Asian and European-ancestry populations. This study identified three new CRC susceptibility loci and provides additional insight into the genetics and biology of CRC.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfNATURE GENETICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAsian Continental Ancestry Group/genetics-
dc.subject.MESHChromosomes, Human, Pair 12/genetics*-
dc.subject.MESHChromosomes, Human, Pair 20/genetics*-
dc.subject.MESHChromosomes, Human, Pair 5/genetics*-
dc.subject.MESHColorectal Neoplasms/genetics*-
dc.subject.MESHCyclin D2/genetics-
dc.subject.MESHEuropean Continental Ancestry Group/genetics-
dc.subject.MESHFar East-
dc.subject.MESHGenetic Predisposition to Disease/genetics*-
dc.subject.MESHGenetics, Population-
dc.subject.MESHGenome, Human/genetics*-
dc.subject.MESHGenome-Wide Association Study-
dc.subject.MESHGenotype-
dc.subject.MESHHumans-
dc.subject.MESHOdds Ratio-
dc.subject.MESHPolymorphism, Single Nucleotide/genetics-
dc.subject.MESHPrincipal Component Analysis-
dc.titleGenome-wide association analyses in east Asians identify new susceptibility loci for colorectal cancer-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health (보건대학원)-
dc.contributor.departmentGraduate School of Public Health (보건대학원)-
dc.contributor.googleauthorWei-Hua Jia-
dc.contributor.googleauthorBen Zhang-
dc.contributor.googleauthorKeitaro Matsuo-
dc.contributor.googleauthorAesun Shin-
dc.contributor.googleauthorYong-Bing Xiang-
dc.contributor.googleauthorSun Ha Jee-
dc.contributor.googleauthorDong-Hyun Kim-
dc.contributor.googleauthorZefang Ren-
dc.contributor.googleauthorQiuyin Cai-
dc.contributor.googleauthorJirong Long-
dc.contributor.googleauthorJiajun Shi-
dc.contributor.googleauthorWanqing Wen-
dc.contributor.googleauthorGong Yang-
dc.contributor.googleauthorRyan J Delahanty-
dc.contributor.googleauthorGenetics and Epidemiology of Colorectal Cancer Consortium (GECCO)-
dc.contributor.googleauthorColon Cancer Family Registry (CCFR)-
dc.contributor.googleauthorBu-Tian Ji-
dc.contributor.googleauthorZhi-Zhong Pan-
dc.contributor.googleauthorFumihiko Matsuda-
dc.contributor.googleauthorYu-Tang Gao-
dc.contributor.googleauthorJae Hwan Oh-
dc.contributor.googleauthorYoon-Ok Ahn-
dc.contributor.googleauthorEun Jung Park-
dc.contributor.googleauthorHong-Lan Li-
dc.contributor.googleauthorJi Won Park-
dc.contributor.googleauthorJaeseong Jo-
dc.contributor.googleauthorJin-Young Jeong-
dc.contributor.googleauthorSatoyo Hosono-
dc.contributor.googleauthorGraham Casey-
dc.contributor.googleauthorUlrike Peters-
dc.contributor.googleauthorXiao-Ou Shu-
dc.contributor.googleauthorYi-Xin Zeng-
dc.contributor.googleauthorWei Zheng-
dc.identifier.doi10.1038/ng.2505-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ02294-
dc.identifier.eissn1546-1718-
dc.identifier.pmid23263487-
dc.identifier.urlhttp://www.nature.com/ng/journal/v45/n2/full/ng.2505.html-
dc.subject.keywordAsian Continental Ancestry Group/genetics-
dc.subject.keywordChromosomes, Human, Pair 12/genetics*-
dc.subject.keywordChromosomes, Human, Pair 20/genetics*-
dc.subject.keywordChromosomes, Human, Pair 5/genetics*-
dc.subject.keywordColorectal Neoplasms/genetics*-
dc.subject.keywordCyclin D2/genetics-
dc.subject.keywordEuropean Continental Ancestry Group/genetics-
dc.subject.keywordFar East-
dc.subject.keywordGenetic Predisposition to Disease/genetics*-
dc.subject.keywordGenetics, Population-
dc.subject.keywordGenome, Human/genetics*-
dc.subject.keywordGenome-Wide Association Study-
dc.subject.keywordGenotype-
dc.subject.keywordHumans-
dc.subject.keywordOdds Ratio-
dc.subject.keywordPolymorphism, Single Nucleotide/genetics-
dc.subject.keywordPrincipal Component Analysis-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.affiliatedAuthorJee, Sun Ha-
dc.rights.accessRightsnot free-
dc.citation.volume45-
dc.citation.number2-
dc.citation.startPage191-
dc.citation.endPage196-
dc.identifier.bibliographicCitationNATURE GENETICS, Vol.45(2) : 191-196, 2013-
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.