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Changes in the blood–brain barrier status closely correlate with the rate of disease progression in patients with multiple system atrophy: A longitudinal study

 Ji E. Lee  ;  Sook K. Song  ;  Jin Yong Hong  ;  Mun-Kyung Sunwoo  ;  Hyun-Jung Park  ;  Young H. Sohn  ;  Phil Hyu Lee 
 Parkinsonism & Related Disorders, Vol.19(4) : 450-452, 2013 
Journal Title
 Parkinsonism & Related Disorders 
Issue Date
Albumins/cerebrospinal fluid* ; Blood-Brain Barrier/pathology* ; Disease Progression ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Multiple System Atrophy/cerebrospinal fluid ; Multiple System Atrophy/pathology*
Blood–brain barrier ; Disease progression ; Multiple system atrophy ; A longitudinal study
BACKGROUND: The pathomechanisms responsible for disease progression in multiple system atrophy are unknown. The blood-brain barrier status may act as a modifier of disease progression in neurodegenerative diseases. METHODS: We evaluated the 12-month longitudinal change of the blood-brain barrier in 16 multiple system atrophy patients and analyzed its correlation with changes in clinical severity. RESULTS: The baseline blood-brain barrier index did not correlate significantly with change in disease severity. However, changes in the blood-brain barrier indices over 12 months had significant positive correlations with changes in total unified multiple system atrophy rating scale (r = 0.56, p = 0.024) and part II scores (r = 0.56, p = 0.025). These correlation coefficients were higher after adjusting for baseline neurological deficits. CONCLUSIONS: These data suggest that changes in the blood-brain barrier status are closely coupled with the rate of disease progression in multiple system atrophy, potentially acting as a contributor to disease progression.
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1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Park, Hyun Jung(박현정)
Sunwoo, Mun Kyung(선우문경)
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Ji Eun(이지은)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
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