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Changes in the blood–brain barrier status closely correlate with the rate of disease progression in patients with multiple system atrophy: A longitudinal study

Authors
 Ji E. Lee  ;  Sook K. Song  ;  Jin Yong Hong  ;  Mun-Kyung Sunwoo  ;  Hyun-Jung Park  ;  Young H. Sohn  ;  Phil Hyu Lee 
Citation
 Parkinsonism & Related Disorders, Vol.19(4) : 450-452, 2013 
Journal Title
 Parkinsonism & Related Disorders 
ISSN
 1353-8020 
Issue Date
2013
Abstract
BACKGROUND: The pathomechanisms responsible for disease progression in multiple system atrophy are unknown. The blood-brain barrier status may act as a modifier of disease progression in neurodegenerative diseases. METHODS: We evaluated the 12-month longitudinal change of the blood-brain barrier in 16 multiple system atrophy patients and analyzed its correlation with changes in clinical severity. RESULTS: The baseline blood-brain barrier index did not correlate significantly with change in disease severity. However, changes in the blood-brain barrier indices over 12 months had significant positive correlations with changes in total unified multiple system atrophy rating scale (r = 0.56, p = 0.024) and part II scores (r = 0.56, p = 0.025). These correlation coefficients were higher after adjusting for baseline neurological deficits. CONCLUSIONS: These data suggest that changes in the blood-brain barrier status are closely coupled with the rate of disease progression in multiple system atrophy, potentially acting as a contributor to disease progression.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86522
DOI
10.1016/j.parkreldis.2012.12.002
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실)
Yonsei Authors
박현정(Park, Hyun Jung)
선우문경(Sunwoo, Mun Kyung)
손영호(Sohn, Young Ho)
이지은(Lee, Ji Eun)
이필휴(Lee, Phil Hyu)
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Full Text
http://www.sciencedirect.com/science/article/pii/S1353802012004798
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