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Changes in the blood–brain barrier status closely correlate with the rate of disease progression in patients with multiple system atrophy: A longitudinal study

DC FieldValueLanguage
dc.contributor.author박현정-
dc.contributor.author선우문경-
dc.contributor.author손영호-
dc.contributor.author이지은-
dc.contributor.author이필휴-
dc.date.accessioned2014-12-18T08:33:12Z-
dc.date.available2014-12-18T08:33:12Z-
dc.date.issued2013-
dc.identifier.issn1353-8020-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86522-
dc.description.abstractBACKGROUND: The pathomechanisms responsible for disease progression in multiple system atrophy are unknown. The blood-brain barrier status may act as a modifier of disease progression in neurodegenerative diseases. METHODS: We evaluated the 12-month longitudinal change of the blood-brain barrier in 16 multiple system atrophy patients and analyzed its correlation with changes in clinical severity. RESULTS: The baseline blood-brain barrier index did not correlate significantly with change in disease severity. However, changes in the blood-brain barrier indices over 12 months had significant positive correlations with changes in total unified multiple system atrophy rating scale (r = 0.56, p = 0.024) and part II scores (r = 0.56, p = 0.025). These correlation coefficients were higher after adjusting for baseline neurological deficits. CONCLUSIONS: These data suggest that changes in the blood-brain barrier status are closely coupled with the rate of disease progression in multiple system atrophy, potentially acting as a contributor to disease progression.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfPARKINSONISM & RELATED DISORDERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAlbumins/cerebrospinal fluid*-
dc.subject.MESHBlood-Brain Barrier/pathology*-
dc.subject.MESHDisease Progression-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLongitudinal Studies-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultiple System Atrophy/cerebrospinal fluid-
dc.subject.MESHMultiple System Atrophy/pathology*-
dc.titleChanges in the blood–brain barrier status closely correlate with the rate of disease progression in patients with multiple system atrophy: A longitudinal study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Life Science (의생명과학부)-
dc.contributor.googleauthorJi E. Lee-
dc.contributor.googleauthorSook K. Song-
dc.contributor.googleauthorJin Yong Hong-
dc.contributor.googleauthorMun-Kyung Sunwoo-
dc.contributor.googleauthorHyun-Jung Park-
dc.contributor.googleauthorYoung H. Sohn-
dc.contributor.googleauthorPhil Hyu Lee-
dc.identifier.doi10.1016/j.parkreldis.2012.12.002-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01935-
dc.contributor.localIdA01982-
dc.contributor.localIdA03270-
dc.contributor.localIdA03210-
dc.contributor.localIdA01744-
dc.relation.journalcodeJ02468-
dc.identifier.eissn1873-5126-
dc.identifier.pmid23298807-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1353802012004798-
dc.subject.keywordBlood–brain barrier-
dc.subject.keywordDisease progression-
dc.subject.keywordMultiple system atrophy-
dc.subject.keywordA longitudinal study-
dc.contributor.alternativeNamePark, Hyun Jung-
dc.contributor.alternativeNameSunwoo, Mun Kyung-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.alternativeNameLee, Ji Eun-
dc.contributor.alternativeNameLee, Phil Hyu-
dc.contributor.affiliatedAuthorSunwoo, Mun Kyung-
dc.contributor.affiliatedAuthorSohn, Young Ho-
dc.contributor.affiliatedAuthorLee, Phil Hyu-
dc.contributor.affiliatedAuthorLee, Ji Eun-
dc.contributor.affiliatedAuthorPark, Hyun Jung-
dc.rights.accessRightsnot free-
dc.citation.volume19-
dc.citation.number4-
dc.citation.startPage450-
dc.citation.endPage452-
dc.identifier.bibliographicCitationPARKINSONISM & RELATED DISORDERS, Vol.19(4) : 450-452, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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