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Composite Three-Marker Assay for Early Detection of Kidney Cancer

Authors
 Dong Su Kim  ;  Young Deuk Choi  ;  Mihyang Moon  ;  Suki Kang  ;  Jong-Baeck Lim  ;  Kyung Min Kim  ;  Kyung Mok Park  ;  Nam Hoon Cho 
Citation
 CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol.22(3) : 390-398, 2013 
Journal Title
 CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 
ISSN
 1055-9965 
Issue Date
2013
MeSH
Adult ; Biomarkers, Tumor/blood* ; Carcinoma, Papillary/blood ; Carcinoma, Papillary/diagnosis ; Carcinoma, Renal Cell/blood ; Carcinoma, Renal Cell/diagnosis ; Carcinoma, Transitional Cell/blood ; Carcinoma, Transitional Cell/diagnosis ; Case-Control Studies ; Early Diagnosis ; Female ; Follow-Up Studies ; Humans ; Kidney Neoplasms/blood ; Kidney Neoplasms/diagnosis* ; Male ; Microfilament Proteins/blood* ; Middle Aged ; NM23 Nucleoside Diphosphate Kinases/blood* ; Neoplasm Staging ; Nicotinamide N-Methyltransferase/blood* ; Prognosis
Keywords
Adult ; Biomarkers, Tumor/blood* ; Carcinoma, Papillary/blood ; Carcinoma, Papillary/diagnosis ; Carcinoma, Renal Cell/blood ; Carcinoma, Renal Cell/diagnosis ; Carcinoma, Transitional Cell/blood ; Carcinoma, Transitional Cell/diagnosis ; Case-Control Studies ; Early Diagnosis ; Female ; Follow-Up Studies ; Humans ; Kidney Neoplasms/blood ; Kidney Neoplasms/diagnosis* ; Male ; Microfilament Proteins/blood* ; Middle Aged ; NM23 Nucleoside Diphosphate Kinases/blood* ; Neoplasm Staging ; Nicotinamide N-Methyltransferase/blood* ; Prognosis
Abstract
BACKGROUND: Early detection of renal cell carcinoma using serum/plasma biomarkers remains challenging. To validate clinical performance of potential candidate markers for kidney tumors, three-marker assay composed of nicotinamide N-methyltransferase (NNMT), L-plastin (LCP1), and nonmetastatic cells 1 protein (NM23A) was evaluated. METHODS: Patients with kidney cancer and control group were included in the clinical evaluation. Participants were divided into cohorts representing the training group of control group including healthy and benign tumors (n = 102) and patients with kidney cancer (n = 87) that were used to identify criteria for scoring. Then, we developed a three-marker assay that was validated with a cohort of test group samples (n = 100). A scoring method based on the cut-point of each of the three markers was used to evaluate the diagnostic performance of the marker combination. RESULTS: Plasma levels of NNMT, LCP1, and NM23A were highly elevated in patients with kidney cancer (P < 0.0001). In 289 blind sample tests with control subjects (n = 175) and patients with kidney cancer (n = 114), the diagnostic accuracy of NNMT alone and the three-marker assay was 0.913 and 0.932, respectively. When 90% specificity was defined, the sensitivity of NNMT and the three-marker assay was 71.9% and 95.7%, respectively. The predictive value of the three-marker assay was 87.2% (+PPV) and 97% (-PPV). CONCLUSIONS: The composite assay with NNMT, LCP1, and NM23A was a promising novel serum marker assay for the early detection of malignant kidney tumors covering subtypes of RCC with high diagnostic characteristics. Impact: NNMT/LCP1/NM23A triple markers could be a helpful screening assay to detect early RCC.
Files in This Item:
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DOI
10.1158/1055-9965.EPI-12-1156
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Suki(강숙희) ORCID logo https://orcid.org/0000-0002-9957-3479
Lim, Jong Baeck(임종백) ORCID logo https://orcid.org/0000-0003-0419-0422
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86485
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