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Composite Three-Marker Assay for Early Detection of Kidney Cancer

Authors
 Dong Su Kim  ;  Young Deuk Choi  ;  Mihyang Moon  ;  Suki Kang  ;  Jong-Baeck Lim  ;  Kyung Min Kim  ;  Kyung Mok Park  ;  Nam Hoon Cho 
Citation
 Cancer Epidemiology Biomarkers & Prevention, Vol.22(3) : 390-398, 2013 
Journal Title
 Cancer Epidemiology Biomarkers & Prevention 
ISSN
 1055-9965 
Issue Date
2013
Abstract
BACKGROUND: Early detection of renal cell carcinoma using serum/plasma biomarkers remains challenging. To validate clinical performance of potential candidate markers for kidney tumors, three-marker assay composed of nicotinamide N-methyltransferase (NNMT), L-plastin (LCP1), and nonmetastatic cells 1 protein (NM23A) was evaluated. METHODS: Patients with kidney cancer and control group were included in the clinical evaluation. Participants were divided into cohorts representing the training group of control group including healthy and benign tumors (n = 102) and patients with kidney cancer (n = 87) that were used to identify criteria for scoring. Then, we developed a three-marker assay that was validated with a cohort of test group samples (n = 100). A scoring method based on the cut-point of each of the three markers was used to evaluate the diagnostic performance of the marker combination. RESULTS: Plasma levels of NNMT, LCP1, and NM23A were highly elevated in patients with kidney cancer (P < 0.0001). In 289 blind sample tests with control subjects (n = 175) and patients with kidney cancer (n = 114), the diagnostic accuracy of NNMT alone and the three-marker assay was 0.913 and 0.932, respectively. When 90% specificity was defined, the sensitivity of NNMT and the three-marker assay was 71.9% and 95.7%, respectively. The predictive value of the three-marker assay was 87.2% (+PPV) and 97% (-PPV). CONCLUSIONS: The composite assay with NNMT, LCP1, and NM23A was a promising novel serum marker assay for the early detection of malignant kidney tumors covering subtypes of RCC with high diagnostic characteristics. Impact: NNMT/LCP1/NM23A triple markers could be a helpful screening assay to detect early RCC.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86485
DOI
10.1158/1055-9965.EPI-12-1156
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실)
Yonsei Authors
강숙희(Kang, Suki) ; 임종백(Lim, Jong Baeck) ; 조남훈(Cho, Nam Hoon) ; 최영득(Choi, Young Deuk)
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