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Fibroblast Growth Factor Receptor 1 Gene Amplification Is Associated With Poor Survival and Cigarette Smoking Dosage in Patients With Resected Squamous Cell Lung Cancer

Authors
 Hye Ryun Kim  ;  Dae Joon Kim  ;  Dae Ryong Kang  ;  Jin Gu Lee  ;  Sun Min Lim  ;  Chang Young Lee  ;  Sun Young Rha  ;  Mi Kyung Bae  ;  Young Joo Lee  ;  Se Hoon Kim  ;  Sang-Jun Ha  ;  Ross Andrew Soo  ;  Kyung Young Chung  ;  Joo Hang Kim  ;  Ji Hyun Lee  ;  Hyo Sup Shim  ;  Byoung Chul Cho 
Citation
 Journal of Clinical Oncology, Vol.31(6) : 731-737, 2013 
Journal Title
 Journal of Clinical Oncology 
ISSN
 0732-183X 
Issue Date
2013
Abstract
PURPOSE: To investigate the frequency and the prognostic role of fibroblast growth factor receptor 1 (FGFR1) amplification in patients with surgically resected squamous cell carcinoma of the lung (SCCL) and the association between smoking and FGFR1 amplification. PATIENTS AND METHODS: Gene copy number of FGFR1 was investigated in microarrayed tumors from 262 patients with SCCL who had tumor tissue as well as smoking and survival data available. Gene copy number was evaluated by fluorescent in situ hybridization, and an FGFR1-amplified tumor (FGFR1 amp(+)) was prespecified as a tumor with nine or more copies of FGFR1. RESULTS: Among 262 patients, the frequency of FGFR1 amp(+) was 13.0%. Patients with FGFR1 amp(+) had significantly shorter disease-free survival (DFS; 26.9 v 94.6 months; P < .001) as well as shorter overall survival (OS; 51.2 v 115.0 months; P = .002) than those without FGFR1 amp(+). Multivariate modeling confirmed that patients with FGFR1 amp(+) had a significantly greater risk of recurrence and death than those without FGFR1 amp(+) after adjusting for sex, smoking status, pathologic stage, and adjuvant chemotherapy (DFS: adjusted hazard ratio [AHR], 2.24; 95% CI, 1.45 to 3.45; P < .001; OS: AHR, 1.83; 95% CI, 1.15 to 2.89; P = .01). The frequency of FGFR1 amp(+) was significantly higher in current smokers than in former smokers and never-smokers (28.9% v 2.5% v 0%; P(trend) < .001). As the smoking dosage increased, so did the incidence of FGFR1 amp(+) (P(trend) = .002). CONCLUSION: FGFR1 amplification is an independent negative prognostic factor in surgically resected SCCL and is associated with cigarette smoking in a dose-dependent manner. FGFR1 amplification is a relevant therapeutic target in Asian patients with SCCL.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86471
Full Text
http://jco.ascopubs.org/content/31/6/731.long
DOI
10.1200/JCO.2012.43.8622
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Research Center for Human Natural Defense System (생체방어연구센터)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실)
Yonsei Authors
강대용(Kang, Dae Ryong)
김대준(Kim, Dae Joon)
김세훈(Kim, Se Hoon)
김주항(Kim, Joo Hang)
김혜련(Kim, Hye Ryun)
라선영(Rha, Sun Young)
배미경(Bae, Mi Kyung)
심효섭(Shim, Hyo Sup) ORCID logo https://orcid.org/0000-0002-5718-3624
이지현(Lee, Ji Hyun)
이진구(Lee, Jin Gu)
이창영(Lee, Chang Young)
임선민(Lim, Sun Min)
정경영(Chung, Kyung Young)
조병철(Cho, Byoung Chul)
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