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Colon carcinoma in childhood: review of the literature with four case reports.

Authors
 Gangmi Kim ; Seung Hyuk Baik ; Nam Kyu Kim ; Chuhl Joo Lyu ; Byung Soh Min ; Hyuk Hur ; Kang Young Lee 
Citation
 International Journal of Colorectal Disease, Vol.28(2) : 157~164, 2013 
Journal Title
 International Journal of Colorectal Disease 
ISSN
 0179-1958 
Issue Date
2013
Abstract
PURPOSE: Colorectal cancer (CRC) in childhood is extremely rare, and only a few case reports exist. We hereby present four cases of childhood CRC along with a literature review. METHODS: A retrospective review of four cases from our institute was conducted, and 15 articles from PubMed describing childhood CRC were reviewed. RESULTS: Case reports: Four patients ranging in age from 11 to 14 years were treated for colon cancer between the years 2000 and 2011. The presenting symptoms varied and included abdominal pain, nausea, vomiting, diarrhea, constipation, and hematochezia, with symptom duration ranging from a few days to 4 months. No patient had a predisposing disease or syndrome. All patients underwent surgical resections, with the most prevalent histology being mucinous adenocarcinoma. Despite radical surgery followed by systemic chemotherapy, the disease progressed in all patients. Literature review: A total of 239 cases were reviewed. The youngest patient was 6 years old. The most frequent predisposing conditions were hereditary nonpolyposis colorectal cancer and familial adenomatous polyposis. Most of the patients presented advanced stage, with the most common histopathologic diagnosis being mucinous adenocarcinoma, followed by poorly differentiated adenocarcinoma and signet ring cell carcinoma. Even though most of the patients underwent aggressive treatment, the overall prognosis was poor. CONCLUSIONS: Childhood CRC has an aggressive pathology and distinct genetic features, which result in an advanced stage at diagnosis and consequently a poor prognosis. Although the incidence is very low, every physician should be aware of CRC as a possible childhood diagnosis.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86395
DOI
10.1007/s00384-012-1603-7
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pediatrics
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
Yonsei Authors
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Link
 http://link.springer.com/article/10.1007%2Fs00384-012-1603-7
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