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Signet Ring Cell Mixed Histology May Show More Aggressive Behavior Than Other Histologies in Early Gastric Cancer

Authors
 Cheal Wung Huh  ;  Da Hyun Jung  ;  Jie-Hyun Kim  ;  Yong Chan Lee  ;  Hyunki Kim  ;  Hoguen Kim  ;  Sun Och Yoon  ;  Young Hoon Youn  ;  Hyojin Park  ;  Sang In Lee  ;  Seung Ho Choi  ;  Jae-Ho Cheong  ;  Sung Hoon Noh 
Citation
 Journal of Surgical Oncology, Vol.107(2) : 124-129, 2013 
Journal Title
 Journal of Surgical Oncology 
ISSN
 0022-4790 
Issue Date
2013
Abstract
BACKGROUND: Signet ring cell carcinoma (SRC) of the stomach is known to have different microscopic and biologic characteristics compared to non-SRC. The pathologic report has documented partly SRC component with main histologies. However, the clinical significance of SRC mixture has not been reported. Aim was to investigate clinicopathologic features of mixed-SRC histology in early gastric cancer (EGC). METHODS: Two thousand two hundred eight patients were diagnosed with EGC and underwent surgery. The patients were divided into three groups such as adenocarcinoma with partly SRC (mixed-SRC group), only adenocarcinoma (adenocarcinoma group), and SRC (SRC group). Clinicopathologic characteristics were compared. RESULTS: The SRC group was more associated with younger age, female, mid-body, mucosa-confined, depressed type, lower lymph node metastasis (LNM), lower lymphovascular invasion, and better survival rate than adenocarcinoma group. The mixed-SRC group was more associated with younger age, female, upper-body, and depressed type than adenocarcinoma group, similar to SRC group. However, the mixed-SRC group showed more submucosal invasion, larger size, and higher LNM than other groups. The mixed-SRC component was one of the independent risk factors of LNM. CONCLUSIONS: Mixed-SRC histology in EGC showed more aggressive behavior than other histologies. Clinical considerations of mixed-SRC histology may be helpful to decide on a specific cancer treatment.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86350
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jso.23261/abstract#fn1
DOI
10.1002/jso.23261
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김지현(Kim, Jie-Hyun)
김현기(Kim, Hyunki) ORCID logo https://orcid.org/0000-0003-2292-5584
김호근(Kim, Ho Keun)
노성훈(Noh, Sung Hoon) ORCID logo https://orcid.org/0000-0003-4386-6886
박효진(Park, Hyo Jin)
윤선옥(Yoon, Sun Och) ORCID logo https://orcid.org/0000-0002-5115-1402
윤영훈(Youn, Young Hoon)
이상인(Lee, Sang In)
이용찬(Lee, Yong Chan)
정다현(Jung, Da Hyun)
정재호(Cheong, Jae Ho)
최승호(Choi, Seung Ho)
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