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Signet Ring Cell Mixed Histology May Show More Aggressive Behavior Than Other Histologies in Early Gastric Cancer

Authors
 Cheal Wung Huh  ;  Da Hyun Jung  ;  Sung Hoon Noh  ;  Jae-Ho Cheong  ;  Seung Ho Choi  ;  Sang In Lee  ;  Hyojin Park  ;  Young Hoon Youn  ;  Sun Och Yoon  ;  Hoguen Kim  ;  Hyunki Kim  ;  Yong Chan Lee  ;  Jie-Hyun Kim 
Citation
 Journal of Surgical Oncology, Vol.107(2) : 124-129, 2013 
Journal Title
 Journal of Surgical Oncology 
ISSN
 0022-4790 
Issue Date
2013
Abstract
BACKGROUND: Signet ring cell carcinoma (SRC) of the stomach is known to have different microscopic and biologic characteristics compared to non-SRC. The pathologic report has documented partly SRC component with main histologies. However, the clinical significance of SRC mixture has not been reported. Aim was to investigate clinicopathologic features of mixed-SRC histology in early gastric cancer (EGC). METHODS: Two thousand two hundred eight patients were diagnosed with EGC and underwent surgery. The patients were divided into three groups such as adenocarcinoma with partly SRC (mixed-SRC group), only adenocarcinoma (adenocarcinoma group), and SRC (SRC group). Clinicopathologic characteristics were compared. RESULTS: The SRC group was more associated with younger age, female, mid-body, mucosa-confined, depressed type, lower lymph node metastasis (LNM), lower lymphovascular invasion, and better survival rate than adenocarcinoma group. The mixed-SRC group was more associated with younger age, female, upper-body, and depressed type than adenocarcinoma group, similar to SRC group. However, the mixed-SRC group showed more submucosal invasion, larger size, and higher LNM than other groups. The mixed-SRC component was one of the independent risk factors of LNM. CONCLUSIONS: Mixed-SRC histology in EGC showed more aggressive behavior than other histologies. Clinical considerations of mixed-SRC histology may be helpful to decide on a specific cancer treatment.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86350
DOI
10.1002/jso.23261
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김지현(Kim, Ji Hyun) ; 김현기(Kim, Hyun Ki) ; 김호근(Kim, Ho Keun) ; 노성훈(Noh, Sung Hoon) ; 박효진(Park, Hyo Jin) ; 윤선옥(Yoon, Sun Och) ; 윤영훈(Youn, Young Hoon) ; 이상인(Lee, Sang In) ; 이용찬(Lee, Yong Chan) ; 정다현(Jung, Da Hyun) ; 정재호(Cheong, Jae Ho) ; 최승호(Choi, Seung Ho)
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Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jso.23261/abstract#fn1
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