Cited 24 times in
The Influence of Anti-Platelet Resistance on the Development of Cerebral Ischemic Lesion after Carotid Artery Stenting
DC Field | Value | Language |
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dc.contributor.author | 허지회 | - |
dc.contributor.author | 김동준 | - |
dc.contributor.author | 김병문 | - |
dc.contributor.author | 김영대 | - |
dc.contributor.author | 민필기 | - |
dc.contributor.author | 서상현 | - |
dc.contributor.author | 송태진 | - |
dc.contributor.author | 이경열 | - |
dc.date.accessioned | 2014-12-18T08:26:35Z | - |
dc.date.available | 2014-12-18T08:26:35Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86315 | - |
dc.description.abstract | PURPOSE: Cerebral ischemic lesions are frequently observed after carotid artery stenting (CAS), and anti-platelet agents are used to prevent stent thrombosis and peri-procedural complications. However, despite the premedication, cerebral ischemic lesions are observed, suggesting that they may rather be related to anti-platelet resistance. We, therefore, investigated the effects of anti-platelet resistance on the development of cerebral ischemic lesions after CAS. MATERIALS AND METHODS: We retrospectively reviewed patients who received CAS and selected patients for whom brain MRI was performed within 24 hours after CAS and for whom anti-platelet resistance was checked. Anti-platelet resistance was examined by the VerifyNow system. We analyzed the correlation between anti-platelet resistance and cerebral ischemic lesions detected on follow-up MRI. RESULTS: Among 76 patients, 45 (59.2%) developed new ischemic lesions after CAS. Twelve (15.8%) patients showed aspirin resistance and 50 (65.8%) patients showed clopidogrel resistance. Patients with a new ischemic lesion demonstrated a significantly greater frequency of clopidogrel resistance than those who had no new ischemic lesion (82.2% versus 41.9%, p=0.001). The frequency of aspirin resistance was not significantly different between the groups of patients with and without new ischemic lesions (20.0% versus 9.7%, p=0.340). In multivariate analysis, clopidogrel resistance was a significant risk factor for post-procedural cerebral ischemia. CONCLUSION: Anti-platelet resistance can be used to predict new ischemic lesions after CAS. Anti-platelet resistance should be evaluated in all patients prior to CAS to prevent ischemic complications related to CAS. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aspirin/therapeutic use* | - |
dc.subject.MESH | Brain Ischemia/diagnosis | - |
dc.subject.MESH | Brain Ischemia/etiology* | - |
dc.subject.MESH | Carotid Arteries/surgery* | - |
dc.subject.MESH | Drug Resistance* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Platelet Aggregation Inhibitors/therapeutic use* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Stents/adverse effects* | - |
dc.title | The Influence of Anti-Platelet Resistance on the Development of Cerebral Ischemic Lesion after Carotid Artery Stenting | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Tae-Jin Song | - |
dc.contributor.googleauthor | Sang Hyun Suh | - |
dc.contributor.googleauthor | Pil-Ki Min | - |
dc.contributor.googleauthor | Dong Joon Kim | - |
dc.contributor.googleauthor | Byung Moon Kim | - |
dc.contributor.googleauthor | Ji Hoe Heo | - |
dc.contributor.googleauthor | Young-Dae Kim | - |
dc.contributor.googleauthor | Kyung-Yul Lee | - |
dc.identifier.doi | 10.3349/ymj.2013.54.2.288 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04369 | - |
dc.contributor.localId | A00410 | - |
dc.contributor.localId | A00498 | - |
dc.contributor.localId | A00702 | - |
dc.contributor.localId | A01412 | - |
dc.contributor.localId | A01886 | - |
dc.contributor.localId | A02073 | - |
dc.contributor.localId | A02648 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 23364958 | - |
dc.subject.keyword | Cerebral infarction | - |
dc.subject.keyword | aspirin resistance | - |
dc.subject.keyword | clopidogrel resistance | - |
dc.subject.keyword | carotid artery stent | - |
dc.contributor.alternativeName | Heo, Ji Hoe | - |
dc.contributor.alternativeName | Kim, Dong Joon | - |
dc.contributor.alternativeName | Kim, Byung Moon | - |
dc.contributor.alternativeName | Kim, Young Dae | - |
dc.contributor.alternativeName | Min, Pil Ki | - |
dc.contributor.alternativeName | Suh, Sang Hyun | - |
dc.contributor.alternativeName | Song, Tae Jin | - |
dc.contributor.alternativeName | Lee, Kyung Yul | - |
dc.contributor.affiliatedAuthor | Heo, Ji Hoe | - |
dc.contributor.affiliatedAuthor | Kim, Dong Joon | - |
dc.contributor.affiliatedAuthor | Kim, Byung Moon | - |
dc.contributor.affiliatedAuthor | Kim, Young Dae | - |
dc.contributor.affiliatedAuthor | Min, Pil Ki | - |
dc.contributor.affiliatedAuthor | Suh, Sang Hyun | - |
dc.contributor.affiliatedAuthor | Song, Tae Jin | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Yul | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 54 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 288 | - |
dc.citation.endPage | 294 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.54(2) : 288-294, 2013 | - |
dc.identifier.rimsid | 28912 | - |
dc.type.rims | ART | - |
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