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Usefulness of the delta neutrophil index for assessing neonatal sepsis

 Soon M Lee  ;  Ho S Eun  ;  Ran Namgung  ;  Min S Park  ;  Kook I Park  ;  Chul Lee 
 ACTA PAEDIATRICA, Vol.102(1) : 13-16, 2013 
Journal Title
Issue Date
Female ; Granulocytes ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases/blood* ; Infant, Newborn, Diseases/diagnosis* ; Leukocyte Count/methods* ; Male ; Retrospective Studies ; Sepsis/blood* ; Sepsis/diagnosis*
CRP ; Delta neutrophil index ; Mortality ; Neonatalsepsis
AIM: We investigated the significance of the calculated delta neutrophil index (DNI) as a diagnostic factor for neonatal sepsis. METHODS: In retrospective study, 24 infants were diagnosed with blood culture-proven sepsis, and 48 non-septic neonates matched for gestational age, and birth weight served as controls. Among the 24 infants with sepsis, 5 died within 7 days at diagnosis. RESULTS: Mean DNI (at diagnosis, after 24 h and 72 h), CRP and WBC counts were significantly higher, and neutrophil and platelet counts were significantly lower in sepsis group than control group. In sepsis group, mean DNI at the time of diagnosis, DNI at 72 h, and CRP at 72 h were significantly higher, and platelet counts were significantly lower for patients with sepsis who died compared with those who survived. In multiple logistic regression analysis, mortality in neonates with sepsis significantly correlated with DNI at 72 h (OR 1.47, 95% CI 1.1-5.6, p = 0.032) and with platelet count (OR 0.93, 95% CI 0.51-0.99, p = 0.014). ROC analysis for DNI at 72 h revealed a cut-off value of 12%, which predicted mortality with 81% sensitivity and 87% specificity. CONCLUSION: DNI may be a valuable tool in assessing the prognosis of patients with neonatal sepsis
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Namgung, Ran(남궁란) ORCID logo https://orcid.org/0000-0001-7182-9535
Park, Kook In(박국인) ORCID logo https://orcid.org/0000-0001-8499-9293
Park, Min Soo(박민수) ORCID logo https://orcid.org/0000-0002-4395-9938
Eun, Ho Seon(은호선) ORCID logo https://orcid.org/0000-0001-7212-0341
Lee, Soon Min(이순민) ORCID logo https://orcid.org/0000-0003-0174-1065
Lee, Chul(이철)
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