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Ultraviolet B activated 1,25(OH)2D affects the level of fibroblast growth factor-23 in human

 Ju Hee Lee  ;  Kyoung Min Kim  ;  Dong Yeob Shin  ;  Han Seok Choi  ;  Do Young Kim  ;  Yoon Kee Park  ;  Sung-Kil Lim  ;  Yumie Rhee 
 ENDOCRINE JOURNAL, Vol.60(1) : 81-86, 2013 
Journal Title
Issue Date
Adult ; Calcium/blood ; Female ; Fibroblast Growth Factors/blood* ; Humans ; Male ; Phosphates/blood ; Ultraviolet Rays* ; Vitamin D/analogs & derivatives* ; Vitamin D/blood
Fibroblast growth factor 23 ; Ultraviolet B ; Vitamin D
Fibroblast growth factor 23 (FGF-23) is known as a phosphaturic factor regulating phosphate homeostasis. Several studies suggest that dietary phosphate, serum phosphate and 1,25-dihydroxyvitamin D [1,25(OH)(2)D] are candidate regulators of FGF-23. While the human studies, which modulated the dietary or serum phosphate showed in rather controversial results, manipulation of the active vitamin D definitely affected FGF-23 in animals. This study was conducted to elucidate the relationship between active vitamin D directly stimulated by ultraviolet B (UVB) exposure and FGF-23 level in human. Ten healthy young adults were recruited to get the UVB exposure thrice a week at sub-minimal erythemal dose with gradual increment by 10% only for 4 weeks. Serum calcium, phosphate, mineral-related hormones and bone turnover markers were analyzed before and after the UVB exposure every 4 week for 12 whole weeks. Twenty five-hydroxyvitamin D [25(OH)D] increased by 115% (19.8 ng/mL to 40.5 ng/mL, p < 0.001) after 4 weeks of UVB exposure. While 1,25(OH)(2)D increased by 75% (49.9 pg/mL to 64.4 pg/mL, p < 0.001) then both level decreased after 4 weeks of withdrawal. C-telopeptide peaked at 2nd week then decreased, while osteocalcin increased gradually. FGF-23 started to increase from the 4th week of UVB exposure then significantly at the 4th week after withdrawal of UVB (27.8 pg/mL to 41.4 pg/mL, p < 0.05). UVB exposure effectively increased 1,25(OH)(2)D with delayed stimulatory effect on FGF-23. This result could support the regulatory loop of 1,25(OH)(2)D and FGF-23 in human, FGF-23 regulation by 1,25(OH)(2)D.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Min(김경민)
Kim, Do Young(김도영)
Park, Yoon Kee(박윤기)
Shin, Dong Yeob(신동엽) ORCID logo https://orcid.org/0000-0003-1048-7978
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Lee, Ju Hee(이주희) ORCID logo https://orcid.org/0000-0002-1739-5956
Lim, Sung Kil(임승길)
Choi, Han Seok(최한석)
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