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Ultraviolet B activated 1,25(OH)2D affects the level of fibroblast growth factor-23 in human

DC FieldValueLanguage
dc.contributor.author박윤기-
dc.contributor.author신동엽-
dc.contributor.author이유미-
dc.contributor.author이주희-
dc.contributor.author임승길-
dc.contributor.author최한석-
dc.contributor.author김경민-
dc.contributor.author김도영-
dc.date.accessioned2014-12-18T08:24:05Z-
dc.date.available2014-12-18T08:24:05Z-
dc.date.issued2013-
dc.identifier.issn0918-8959-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86236-
dc.description.abstractFibroblast growth factor 23 (FGF-23) is known as a phosphaturic factor regulating phosphate homeostasis. Several studies suggest that dietary phosphate, serum phosphate and 1,25-dihydroxyvitamin D [1,25(OH)(2)D] are candidate regulators of FGF-23. While the human studies, which modulated the dietary or serum phosphate showed in rather controversial results, manipulation of the active vitamin D definitely affected FGF-23 in animals. This study was conducted to elucidate the relationship between active vitamin D directly stimulated by ultraviolet B (UVB) exposure and FGF-23 level in human. Ten healthy young adults were recruited to get the UVB exposure thrice a week at sub-minimal erythemal dose with gradual increment by 10% only for 4 weeks. Serum calcium, phosphate, mineral-related hormones and bone turnover markers were analyzed before and after the UVB exposure every 4 week for 12 whole weeks. Twenty five-hydroxyvitamin D [25(OH)D] increased by 115% (19.8 ng/mL to 40.5 ng/mL, p < 0.001) after 4 weeks of UVB exposure. While 1,25(OH)(2)D increased by 75% (49.9 pg/mL to 64.4 pg/mL, p < 0.001) then both level decreased after 4 weeks of withdrawal. C-telopeptide peaked at 2nd week then decreased, while osteocalcin increased gradually. FGF-23 started to increase from the 4th week of UVB exposure then significantly at the 4th week after withdrawal of UVB (27.8 pg/mL to 41.4 pg/mL, p < 0.05). UVB exposure effectively increased 1,25(OH)(2)D with delayed stimulatory effect on FGF-23. This result could support the regulatory loop of 1,25(OH)(2)D and FGF-23 in human, FGF-23 regulation by 1,25(OH)(2)D.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfENDOCRINE JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHCalcium/blood-
dc.subject.MESHFemale-
dc.subject.MESHFibroblast Growth Factors/blood*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHPhosphates/blood-
dc.subject.MESHUltraviolet Rays*-
dc.subject.MESHVitamin D/analogs & derivatives*-
dc.subject.MESHVitamin D/blood-
dc.titleUltraviolet B activated 1,25(OH)2D affects the level of fibroblast growth factor-23 in human-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학)-
dc.contributor.googleauthorJu Hee Lee-
dc.contributor.googleauthorKyoung Min Kim-
dc.contributor.googleauthorDong Yeob Shin-
dc.contributor.googleauthorHan Seok Choi-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorYoon Kee Park-
dc.contributor.googleauthorSung-Kil Lim-
dc.contributor.googleauthorYumie Rhee-
dc.identifier.doi10.1507/endocrj.EJ12-0199-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01595-
dc.contributor.localIdA02093-
dc.contributor.localIdA03012-
dc.contributor.localIdA03375-
dc.contributor.localIdA04206-
dc.contributor.localIdA00295-
dc.contributor.localIdA03171-
dc.contributor.localIdA00385-
dc.relation.journalcodeJ00769-
dc.identifier.eissn1348-4540-
dc.identifier.pmid22986488-
dc.subject.keywordFibroblast growth factor 23-
dc.subject.keywordUltraviolet B-
dc.subject.keywordVitamin D-
dc.contributor.alternativeNamePark, Yoon Kee-
dc.contributor.alternativeNameShin, Dong Yeob-
dc.contributor.alternativeNameRhee, Yumie-
dc.contributor.alternativeNameLee, Ju Hee-
dc.contributor.alternativeNameLim, Sung Kil-
dc.contributor.alternativeNameChoi, Han Seok-
dc.contributor.alternativeNameKim, Kyung Min-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.affiliatedAuthorPark, Yoon Kee-
dc.contributor.affiliatedAuthorShin, Dong Yeob-
dc.contributor.affiliatedAuthorRhee, Yumie-
dc.contributor.affiliatedAuthorLim, Sung Kil-
dc.contributor.affiliatedAuthorChoi, Han Seok-
dc.contributor.affiliatedAuthorKim, Kyung Min-
dc.contributor.affiliatedAuthorLee, Ju Hee-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.rights.accessRightsfree-
dc.citation.volume60-
dc.citation.number1-
dc.citation.startPage81-
dc.citation.endPage86-
dc.identifier.bibliographicCitationENDOCRINE JOURNAL, Vol.60(1) : 81-86, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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