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Ultraviolet B activated 1,25(OH)2D affects the level of fibroblast growth factor-23 in human
DC Field | Value | Language |
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dc.contributor.author | 박윤기 | - |
dc.contributor.author | 신동엽 | - |
dc.contributor.author | 이유미 | - |
dc.contributor.author | 이주희 | - |
dc.contributor.author | 임승길 | - |
dc.contributor.author | 최한석 | - |
dc.contributor.author | 김경민 | - |
dc.contributor.author | 김도영 | - |
dc.date.accessioned | 2014-12-18T08:24:05Z | - |
dc.date.available | 2014-12-18T08:24:05Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0918-8959 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86236 | - |
dc.description.abstract | Fibroblast growth factor 23 (FGF-23) is known as a phosphaturic factor regulating phosphate homeostasis. Several studies suggest that dietary phosphate, serum phosphate and 1,25-dihydroxyvitamin D [1,25(OH)(2)D] are candidate regulators of FGF-23. While the human studies, which modulated the dietary or serum phosphate showed in rather controversial results, manipulation of the active vitamin D definitely affected FGF-23 in animals. This study was conducted to elucidate the relationship between active vitamin D directly stimulated by ultraviolet B (UVB) exposure and FGF-23 level in human. Ten healthy young adults were recruited to get the UVB exposure thrice a week at sub-minimal erythemal dose with gradual increment by 10% only for 4 weeks. Serum calcium, phosphate, mineral-related hormones and bone turnover markers were analyzed before and after the UVB exposure every 4 week for 12 whole weeks. Twenty five-hydroxyvitamin D [25(OH)D] increased by 115% (19.8 ng/mL to 40.5 ng/mL, p < 0.001) after 4 weeks of UVB exposure. While 1,25(OH)(2)D increased by 75% (49.9 pg/mL to 64.4 pg/mL, p < 0.001) then both level decreased after 4 weeks of withdrawal. C-telopeptide peaked at 2nd week then decreased, while osteocalcin increased gradually. FGF-23 started to increase from the 4th week of UVB exposure then significantly at the 4th week after withdrawal of UVB (27.8 pg/mL to 41.4 pg/mL, p < 0.05). UVB exposure effectively increased 1,25(OH)(2)D with delayed stimulatory effect on FGF-23. This result could support the regulatory loop of 1,25(OH)(2)D and FGF-23 in human, FGF-23 regulation by 1,25(OH)(2)D. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ENDOCRINE JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Calcium/blood | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibroblast Growth Factors/blood* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Phosphates/blood | - |
dc.subject.MESH | Ultraviolet Rays* | - |
dc.subject.MESH | Vitamin D/analogs & derivatives* | - |
dc.subject.MESH | Vitamin D/blood | - |
dc.title | Ultraviolet B activated 1,25(OH)2D affects the level of fibroblast growth factor-23 in human | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | Ju Hee Lee | - |
dc.contributor.googleauthor | Kyoung Min Kim | - |
dc.contributor.googleauthor | Dong Yeob Shin | - |
dc.contributor.googleauthor | Han Seok Choi | - |
dc.contributor.googleauthor | Do Young Kim | - |
dc.contributor.googleauthor | Yoon Kee Park | - |
dc.contributor.googleauthor | Sung-Kil Lim | - |
dc.contributor.googleauthor | Yumie Rhee | - |
dc.identifier.doi | 10.1507/endocrj.EJ12-0199 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01595 | - |
dc.contributor.localId | A02093 | - |
dc.contributor.localId | A03012 | - |
dc.contributor.localId | A03375 | - |
dc.contributor.localId | A04206 | - |
dc.contributor.localId | A00295 | - |
dc.contributor.localId | A03171 | - |
dc.contributor.localId | A00385 | - |
dc.relation.journalcode | J00769 | - |
dc.identifier.eissn | 1348-4540 | - |
dc.identifier.pmid | 22986488 | - |
dc.subject.keyword | Fibroblast growth factor 23 | - |
dc.subject.keyword | Ultraviolet B | - |
dc.subject.keyword | Vitamin D | - |
dc.contributor.alternativeName | Park, Yoon Kee | - |
dc.contributor.alternativeName | Shin, Dong Yeob | - |
dc.contributor.alternativeName | Rhee, Yumie | - |
dc.contributor.alternativeName | Lee, Ju Hee | - |
dc.contributor.alternativeName | Lim, Sung Kil | - |
dc.contributor.alternativeName | Choi, Han Seok | - |
dc.contributor.alternativeName | Kim, Kyung Min | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.affiliatedAuthor | Park, Yoon Kee | - |
dc.contributor.affiliatedAuthor | Shin, Dong Yeob | - |
dc.contributor.affiliatedAuthor | Rhee, Yumie | - |
dc.contributor.affiliatedAuthor | Lim, Sung Kil | - |
dc.contributor.affiliatedAuthor | Choi, Han Seok | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Min | - |
dc.contributor.affiliatedAuthor | Lee, Ju Hee | - |
dc.contributor.affiliatedAuthor | Kim, Do Young | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 60 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 81 | - |
dc.citation.endPage | 86 | - |
dc.identifier.bibliographicCitation | ENDOCRINE JOURNAL, Vol.60(1) : 81-86, 2013 | - |
dc.identifier.rimsid | 28864 | - |
dc.type.rims | ART | - |
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