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Small-world networks in individuals at ultra-high risk for psychosis and first-episode schizophrenia during a working memory task

Authors
 Kyungun Jhung  ;  Sung-Hwan Cho  ;  Ji-Hyun Jang  ;  Jin Young Park  ;  Dongkwan Shin  ;  Kyung Ran Kim  ;  Eun Lee  ;  Kwang-Hyun Cho  ;  Suk Kyoon An 
Citation
 NEUROSCIENCE LETTERS, Vol.535 : 35-39, 2013 
Journal Title
 NEUROSCIENCE LETTERS 
ISSN
 0304-3940 
Issue Date
2013
MeSH
Brain/physiopathology* ; Female ; Humans ; Male ; Memory, Short-Term ; Nerve Net/physiopathology* ; Psychotic Disorders/physiopathology* ; Psychotic Disorders/psychology ; Risk ; Schizophrenia/physiopathology* ; Schizophrenic Psychology* ; Theta Rhythm ; Young Adult
Keywords
Ultra-high risk for psychosis ; First-episode schizophrenia ; Small-world network ; Working memory ; Theta band ; Electroencephalography
Abstract
Disturbances of functional interaction between different brain regions have been hypothesized to be the major pathophysiological mechanism underlying the cognitive deficits of schizophrenia. We investigated the small-world functional networks in individuals at ultra-high risk (UHR) for psychosis, first-episode schizophrenia (FESPR) patients, and healthy controls. All participants underwent the electroencephalogram during a control task and a working memory (WM) task. Small-world properties of the theta band were reduced in FESPR relative to controls during the WM task. Small-worldness of the UHR during the WM task exhibited intermediate value between that of controls and FESPR. These results imply that the suboptimal organization of the brain network may play a pivotal role in the schizophrenia pathophysiology.
Full Text
http://www.sciencedirect.com/science/article/pii/S0304394012015467
DOI
10.1016/j.neulet.2012.11.051
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Ran(김경란) ORCID logo https://orcid.org/0000-0001-8375-1851
Park, Jin Young(박진영) ORCID logo https://orcid.org/0000-0002-5351-9549
An, Suk Kyoon(안석균) ORCID logo https://orcid.org/0000-0003-4576-6184
Lee, Eun(이은) ORCID logo https://orcid.org/0000-0002-7462-0144
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86227
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