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Clinical Implications and Risk Factors of Acute Pancreatitis after Cardiac Valve Surgery

 Joo Won Chung  ;  Sung Ho Ryu  ;  Jung Hyun Jo  ;  Jeong Youp Park  ;  Sak Lee  ;  Seung Woo Park  ;  Si Young Song  ;  Jae Bock Chung 
 YONSEI MEDICAL JOURNAL, Vol.54(1) : 154-159, 2013 
Journal Title
Issue Date
Acute Disease ; Adult ; Aged ; Cardiac Surgical Procedures/adverse effects ; Cardiopulmonary Bypass ; Female ; Heart Valve Diseases/complications* ; Heart Valve Diseases/surgery* ; Heart Valve Prosthesis Implantation/adverse effects* ; Humans ; Lipase/blood ; Male ; Middle Aged ; Multivariate Analysis ; Norepinephrine/therapeutic use ; Pancreatitis/diagnosis* ; Pancreatitis/etiology* ; Postoperative Period ; Prognosis ; Retrospective Studies ; Risk Factors
Acute pancreatitis ; cardiac valve surgery ; cardiopulmonary bypass
PURPOSE: Acute pancreatitis is one of the potentially lethal complications that occurs after cardiac surgery. We tried to identify risk factors for and the prognosis of acute pancreatitis after cardiac valve surgery with cardiopulmonary bypass. MATERIALS AND METHODS: We retrospectively analyzed a database of consecutive patients who underwent cardiac valve surgery with cardiopulmonary bypass between January 2005 and April 2010 at our institution. Patients were classified as having acute pancreatitis based on serum lipase concentration and clinical symptoms (lipase ≥ 180 U/L or ≥ 60 U/L with relevant symptoms). RESULTS: Of the 986 patients who underwent cardiac valve surgery with cardiopulmonary bypass, 58 (5.9%) patients developed post-operative pancreatitis. Post-operative hospital stay was significantly longer (29.7 ± 45.6 days vs. 12.4 ± 10.7 days, p = 0.005) and in-hospital mortality rate was higher (15.5% vs. 2.0%, p<0.001) in patients with post-operative pancreatitis than those without. Hypertension, chronic kidney disease, and peri-operative use of norepinephrine were identified as independent risk factors for developing pancreatitis after cardiac valve surgery. CONCLUSION: We found that acute pancreatitis after cardiac valve surgery requires longer hospitalization and increases the in-hospital mortality rate. Clinicians should be aware that patients could develop pancreatitis after cardiac valve surgery, especially in patients with hypertension and chronic kidney disease treated with norepinephrine.
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1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Seung Woo(박승우) ORCID logo https://orcid.org/0000-0001-8230-964X
Park, Jeong Youp(박정엽) ORCID logo https://orcid.org/0000-0003-0110-8606
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Lee, Sak(이삭) ORCID logo https://orcid.org/0000-0001-6130-2342
Chung, Jae Bock(정재복)
Chung, Joo Won(정주원)
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