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Clinical Implications and Risk Factors of Acute Pancreatitis after Cardiac Valve Surgery

 Joo Won Chung  ;  Sung Ho Ryu  ;  Jung Hyun Jo  ;  Jeong Youp Park  ;  Sak Lee  ;  Seung Woo Park  ;  Si Young Song  ;  Jae Bock Chung 
 Yonsei Medical Journal, Vol.54(1) : 154-159, 2013 
Journal Title
 Yonsei Medical Journal 
Issue Date
PURPOSE: Acute pancreatitis is one of the potentially lethal complications that occurs after cardiac surgery. We tried to identify risk factors for and the prognosis of acute pancreatitis after cardiac valve surgery with cardiopulmonary bypass. MATERIALS AND METHODS: We retrospectively analyzed a database of consecutive patients who underwent cardiac valve surgery with cardiopulmonary bypass between January 2005 and April 2010 at our institution. Patients were classified as having acute pancreatitis based on serum lipase concentration and clinical symptoms (lipase ≥ 180 U/L or ≥ 60 U/L with relevant symptoms). RESULTS: Of the 986 patients who underwent cardiac valve surgery with cardiopulmonary bypass, 58 (5.9%) patients developed post-operative pancreatitis. Post-operative hospital stay was significantly longer (29.7 ± 45.6 days vs. 12.4 ± 10.7 days, p = 0.005) and in-hospital mortality rate was higher (15.5% vs. 2.0%, p<0.001) in patients with post-operative pancreatitis than those without. Hypertension, chronic kidney disease, and peri-operative use of norepinephrine were identified as independent risk factors for developing pancreatitis after cardiac valve surgery. CONCLUSION: We found that acute pancreatitis after cardiac valve surgery requires longer hospitalization and increases the in-hospital mortality rate. Clinicians should be aware that patients could develop pancreatitis after cardiac valve surgery, especially in patients with hypertension and chronic kidney disease treated with norepinephrine.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
박승우(Park, Seung Woo)
박정엽(Park, Jeong Youp)
송시영(Song, Si Young) ORCID logo https://orcid.org/0000-0002-1417-4314
이삭(Lee, Sak)
정재복(Chung, Jae Bock)
정주원(Chung, Joo Won)
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