2 185

Cited 8 times in

Serum carcinoembryonic antigen level is associated with arterial stiffness in healthy Korean adult

 Urhee Bae  ;  Jae Yong Shim  ;  Hye Ree Lee  ;  Jin Young Shin 
 CLINICA CHIMICA ACTA, Vol.415 : 286-289, 2013 
Journal Title
Issue Date
Adult ; Analysis of Variance ; Ankle Brachial Index ; Asian Continental Ancestry Group* ; Biomarkers/blood ; Blood Flow Velocity/physiology ; Blood Pressure/physiology ; Body Mass Index ; Brachial Artery/physiology ; Carcinoembryonic Antigen/blood* ; Cholesterol, LDL/blood ; Exercise ; Female ; Heart Rate/physiology ; Humans ; Male ; Middle Aged ; Sex Factors ; Smoking ; Tibial Arteries/physiology ; Vascular Stiffness/physiology*
Carcinoembryonic antigen ; Brachial-ankle pulse wave velocity ; Vascular stiffness
BACKGROUND: Carcinoembryonic antigen (CEA), a widely used tumor marker, has been reported to be related with atherosclerosis and cardiovascular disease. However, little is known about the relationship between arterial stiffness and CEA level. We assessed whether serum CEA level is related with arterial stiffness by measuring brachial-ankle pulse wave velocity (ba-PWV) in healthy subjects. METHODS: Serum CEA level, ba-PWV and conventional risk factors were measured in 2909 subjects (1767 men and 1142 women) who underwent routine health checkup. We performed correlation, multiple linear regression and multiple logistic regression analyses to divide into quartiles according to CEA level. RESULTS: The mean values of ba-PWV increased gradually by CEA quartile. After correcting for significantly correlated variables, the ba-PWV was independently associated with CEA (P<0.001). The odds ratios (95% CI) for high ba-PWV (>75th percentile; men: 1518 cm/s, women: 1487 cm/s) according to CEA quartile were 1.00 (Q1), 1.044 (0.659-1.652; Q2), 1.075 (0.688-1.681; Q3), and 1.595 (1.009-2.520; Q4) after adjusting for age, blood pressure, BMI, fasting glucose, heart rate, log hs-CRP, LDL-cholesterol, WBC count, alcohol intake, smoking and exercise in men (P<0.001). The odds ratios (95% CIs) in women were 1.00 (Q1), 1.719 (0.971-3.032; Q2), 1.793 (1.019-3.156; Q3), and 2.330 (1.312-4.139; Q4) (P<0.001) after adjusting for age, blood pressure, BMI, fasting glucose, heart rate, log hs-CRP, lipid profile, uric acid, WBC count, alcohol intake, smoking and exercise. CONCLUSIONS: The CEA level is associated with arterial stiffness which measured by ba-PWV in healthy Korean men and women.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jin Young(신진영)
Shim, Jae Yong(심재용) ORCID logo https://orcid.org/0000-0002-9561-9230
Lee, Hye Ree(이혜리)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.