Clinical trial of platelet rich fibrin insertion for exposed dental pulp of second molar associated with impacted third molar: A pilot study

Abstract

Purpose: Root resorption of second molars (M2s) due to impacted third molars (M3s) can result in pulp exposure of second molars. Platelet rich fibrin (PRF) has recently been investigated because of its positive effect on tissue healing. This study aims to determine the clinical utility of applying PRF to pulp exposure site of second molars affected by impacted third molars using radiological and clinical examination. Materials and Methods: Ten patients with exposed pulp of M2 by impacted M3 were evaluated clinically and radiographically before surgery. Extraction of M3 was performed and average follow up period was 8.3 months (ranged from 1 week to 40 months). Extraction was done using conventional method and PRF was applied to pulp exposure site. PRF was obtained by collecting the patient’s blood and spinning it in a centrifuge at 1300 RPM for 15 minutes. After extraction of M3, clinical and radiographic exam was done regularly to evaluate dentin bridge formation, bony healing and viability of M2. Results: In 6 of 10 patients who underwent regular follow-up, dentin bridge formation and bony healing were ob- served radiographically at the site of PRF application. All patients remained free of symptoms implying additional external root resorption or pulp necrosis. Conclusion: This study shows that the application of PRF on M2 pulp exposure site associated with impacted M3 is effective in promoting healing. Although this study demonstrates beneficial effect of PRF, further controlled studies are warranted.. (J Korean Dent Assoc 2025; 63(9): 298-303)