Unexpected delayed orofacial symptoms induced by facial cosmetic filler: A report of 3 cases

Abstract

In addition to well-known side effects such as rash, redness, and bone resorption, unexpected facial complications may occasionally occur several years after certain medical procedures. This report presents rare cases of orofacial symptoms that developed as delayed responses to cosmetic filler injections. Three separate patients presented to the authors' institution with varying severities of orofacial symptoms. These symptoms, initially diagnosed clinically as inflammation or neoplasms of the parotid gland, were later identified through magnetic resonance imaging as diseases potentially associated with filler materials injected approximately 4-8 years earlier. The primary goal of this report was to inform specialists in the oral and maxillofacial field about the possibility of such complications, enabling them to manage patient symptoms effectively and develop appropriate treatment strategies. (Imaging Sci Dent 20250144)