0 14114

Cited 0 times in

Cited 0 times in

Hemagglutinin docking analysis-based visual detection of antiviral therapeutic efficacy of umifenovir against influenza virus

Authors
 Jinyoung Kim  ;  Jong-Woo Lim  ;  Hyun-Ouk Kim  ;  Joowon Park  ;  Eunji Jeong  ;  Chaewon Park  ;  Geunseon Park  ;  Minjoo Yeom  ;  Daesub Song  ;  Eun-Kyung Lim  ;  Seungjoo Haam 
Citation
 BIOSENSORS & BIOELECTRONICS, Vol.287 : 117762, 2025-11 
Journal Title
BIOSENSORS & BIOELECTRONICS
ISSN
 0956-5663 
Issue Date
2025-11
MeSH
Animals ; Antiviral Agents* / chemistry ; Antiviral Agents* / pharmacology ; Biosensing Techniques / methods ; Dogs ; Gold / chemistry ; Hemagglutinin Glycoproteins, Influenza Virus* / chemistry ; Hemagglutinin Glycoproteins, Influenza Virus* / metabolism ; Humans ; Indoles* / chemistry ; Indoles* / pharmacology ; Influenza A virus* / drug effects ; Influenza, Human* / drug therapy ; Influenza, Human* / virology ; Madin Darby Canine Kidney Cells ; Metal Nanoparticles / chemistry ; Molecular Docking Simulation ; Sulfides ; Virus Replication / drug effects
Keywords
Antiviral resistance ; Hemagglutinin molecular docking ; Influenza A virus ; Umifenovir ; Visual detection
Abstract
The rapid evolution of viruses poses a significant threat to global health, as evidenced by recent pandemics. Umifenovir (Arbidol®), a broad-spectrum antiviral drug, has demonstrated potential in treating various viral infections. This study aimed to assess the antiviral mechanism of umifenovir against influenza A virus (IAV), specifically its interaction with hemagglutinin (HA), using umifenovir-modified gold nanoparticles (umi-GNPs). Umi-GNPs have been applied to various IAV subtypes, including H1N1, H3N2, H4N6, H6N8, and H9N2. Our results demonstrate that umifenovir effectively inhibits viral replication in all tested subtypes at a viral titer of 104.5 50 % egg infective dose (EID50)/mL. Additionally, the aggregation of umi-GNPs with viruses pre-bound to umifenovir was suppressed, indicating that umi-GNPs bind to a specific region of the viral protein. These findings indicate that umi-GNPs can serve as novel agents for visually determining umifenovir resistance in IAV.
Full Text
https://www.sciencedirect.com/science/article/pii/S0956566325006384
DOI
10.1016/j.bios.2025.117762
Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/207114
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links