Establishment of Normative Retinal Nerve Fiber Layer Thickness in Healthy Koreans Using Huvitz Optical Coherence Tomography and Comparison with Cirrus OCT

Abstract

Objectives: The purpose of this study was to evaluate the diagnostic accuracy of glaucoma by establishing normative data on retinal nerve fiber layer (RNFL) thickness, specifically for healthy Koreans, using Huvitz spectral-domain optical coherence tomography (OCT). This study also aimed to compare the obtained RNFL thickness data with normative values provided by the Cirrus OCT system to identify any device-specific differences that could impact glaucoma diagnosis. Methods: This prospective observational study included 148 healthy participants aged 20-69 years at Gangnam Severance Hospital. Participants underwent comprehensive ophthalmologic evaluations, including RNFL thickness measurements using Huvitz OCT, which were compared with existing normative Cirrus OCT data. RNFL thickness was analyzed by quadrant (superior, inferior, nasal, and temporal) and clock-hour sectors. Statistical analysis included one-way analysis of variance (ANOVA) for group comparisons and linear regression to assess age-related changes. Results: The average RNFL thickness was 91.13 ± 13 μm, with the thickest measurements in the superior quadrant (111.85 ± 18.53 μm) and the thinnest in the nasal quadrant (68.35 ± 20.03 μm). Significant age-related thinning was observed across all quadrants, particularly the superior and inferior quadrants. Comparison with the Cirrus OCT system revealed significant differences, with the Huvitz OCT results showing thinner RNFL in the superior and inferior quadrants. Conclusions: This study established normative RNFL thickness data in healthy Koreans using Huvitz OCT, providing essential reference data for clinical glaucoma diagnosis. The differences between Huvitz and Cirrus OCT systems underscore the need for device- and population-specific normative data to improve diagnostic accuracy in glaucoma management.