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Pachychoroid Spectrum Disease: Comparison of Patients with Central Serous Chorioretinopathy Complicated with Pachychoroid Neovasculopathy

Authors
 Hyunjean Jung  ;  Youngsong Suh  ;  Junwon Lee  ;  Christopher Seungkyu Lee  ;  Min Kim  ;  Suk Ho Byeon  ;  Sung Soo Kim  ;  Hyun Goo Kang 
Citation
 Korean Journal of Ophthalmology, Vol.38(4) : 304-315, 2024-08 
Journal Title
Korean Journal of Ophthalmology
ISSN
 1011-8942 
Issue Date
2024-08
MeSH
Adult ; Central Serous Chorioretinopathy* / complications ; Central Serous Chorioretinopathy* / diagnosis ; Choroid / blood supply ; Choroid / pathology ; Choroidal Neovascularization / diagnosis ; Female ; Fluorescein Angiography* / methods ; Follow-Up Studies ; Fundus Oculi* ; Humans ; Incidence ; Male ; Middle Aged ; Retrospective Studies ; Subretinal Fluid ; Tomography, Optical Coherence* / methods ; Visual Acuity* ; Young Adult
Keywords
Central serous chorioretinopathy ; Choroidal neovascularization ; Subretinal fluid
Abstract
Purpose: This study aimed to determine the incidence and visual outcomes of pachychoroid neovasculopathy (PNV) in patients initially diagnosed with central serous chorioretinopathy (CSC).

Methods: In this study, 144 patients aged 20 to 55 years with treatment-naive chronic CSC, defined as the persistence of subretinal fluid (SRF) for ≥6 months, were retrospectively enrolled. Patients with PNV at the initial evaluation were categorized as group 1, whereas those who developed new-onset PNV during follow-up were categorized as group 2. Patients without PNV until the end of the follow-up were categorized as group 3.

Results: Over a mean follow-up period of 49.9 ± 39.9 months, new-onset PNV was diagnosed in 11.8% of patients with CSC.

The time taken to reach the initial resolution was longest in group 1 (group 1, 11.13 ± 10.70 months; group 2, 8.14 ± 7.90 months; group 3, 7.32 ± 9.55 months), although these differences were not statistically significant. The numbers of injections needed to achieve initial resolution were 3.76 ± 5.90, 1.64 ± 2.06, and 1.74 ± 4.33 in groups 1, 2, and 3, respectively, with no significant differences. SRF recurrence was recorded in seven patients (29.2%) in group 1, nine (64.3%) in group 2, and 28 (26.7%) in group 3. The recurrence rates were significantly higher in group 2 than those in group 1 or 3. At the end of the follow-up period, significant improvements in best-corrected visual acuity were achieved in groups 1 and 3, compared with baseline, but not in group 2.

Conclusions: Patients with chronic CSC with new-onset PNV exhibited higher SRF recurrence and worse visual outcomes compared to those with initial PNV or those with chronic CSC without PNV. Our study emphasizes the importance of routine screening for prompt diagnoses of new-onset PNV in individuals with chronic CSC.
Files in This Item:
T202406828.pdf Download
DOI
10.3341/kjo.2024.0020
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hyun Goo(강현구) ORCID logo https://orcid.org/0000-0001-8359-9618
Kim, Min(김민) ORCID logo https://orcid.org/0000-0003-1873-6959
Kim, Sung Soo(김성수) ORCID logo https://orcid.org/0000-0002-0574-7993
Byeon, Suk Ho(변석호) ORCID logo https://orcid.org/0000-0001-8101-0830
Lee, Christopher Seungkyu(이승규) ORCID logo https://orcid.org/0000-0001-5054-9470
Lee, Jun Won(이준원) ORCID logo https://orcid.org/0000-0003-0543-7132
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/201278
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