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Potential prognostic value of rheumatoid factor in anti-aquaporin 4-immunoglobin G-positive neuromyelitis optica spectrum disorders

Authors
 Hye Lim Lee  ;  Jin Myoung Seok  ;  Soon-Young Hwang  ;  Eun Bin Cho  ;  Hojin Kim  ;  Ha Young Shin  ;  Byung-Jo Kim  ;  Seol-Hee Baek  ;  Hung Youl Seok  ;  Sa-Yoon Kang  ;  Ohyun Kwon  ;  Young-Min Lim  ;  Sang-Soo Lee  ;  Jeeyoung Oh  ;  So-Young Huh  ;  Jong Kuk Kim  ;  Byeol-A Yoon  ;  Eun-Hee Sohn  ;  Sooyoung Kim  ;  Joong-Yang Cho  ;  Ju-Hong Min  ;  Byoung Joon Kim 
Citation
 JOURNAL OF THE NEUROLOGICAL SCIENCES, Vol.466 : 123215, 2024-11 
Journal Title
JOURNAL OF THE NEUROLOGICAL SCIENCES
ISSN
 0022-510X 
Issue Date
2024-11
MeSH
Adult ; Aquaporin 4* / immunology ; Autoantibodies* / blood ; Female ; Humans ; Male ; Middle Aged ; Neuromyelitis Optica* / blood ; Neuromyelitis Optica* / diagnosis ; Neuromyelitis Optica* / immunology ; Prognosis ; Prospective Studies ; Rheumatoid Factor* / blood ; Young Adult
Keywords
Aquaporin-4 ; Autoantibodies ; Disability ; Multiple sclerosis ; Neuromyelitis optica spectrum disorder ; Rheumatoid factor
Abstract
Background: Neuromyelitis optica spectrum disorder (NMOSD) is the central nervous system demyelinating disease differentiated from multiple sclerosis by the presence of anti-aquaporin 4-antibody (AQP4-ab), which is sometimes accompanied by non-organ-specific autoantibodies. Methods: We prospectively collected clinical information and profiles of non-organ-specific autoantibodies such as fluorescent antinuclear (FANA), anti-Sjögren's syndrome A (SSA)/Ro, anti-SS B (SSB)/La, anti-neutrophil cytoplasmatic (ANCA), lupus anticoagulant (LA), anti-cardiolipin (ACA), anti-double-stranded DNA (dsDNA), rheumatoid factor (RF), anti-thyroperoxidase, and anti-thyroglobulin antibodies in patients with NMOSD. Clinical characteristics and laboratory findings of patients with NMOSD with or without autoantibodies were analyzed. Cox proportional hazard models were used to identify independent risk factors predicting high disability in patients with NMOSD. Results: A total of 158 patients with NMOSD (Female: Male = 146:12; age, 36.11 ± 14.7) were included. FANA was observed most frequently (33.3 %), followed by anti-SSA (28.6 %), anti-SSB (10.0 %), RF (8.5 %), anti-dsDNA (7.0 %), LA (4.7 %), ACA (4.8 %), and ANCA (2.4 %). High disability (Expanded Disability Status Scale (EDSS) score ≥ 6) was observed more frequently in patients with RF (45.5 %) than in those without RF (14.5 %) (p = 0.02). RF was a significant predictive factor for the high disability (hazard ratio [HR], 3.763; 95 % confidence interval [CI], 1.086–13.038; p = 0.037), age at onset (HR, 1.093; 95 % CI, 1.05–1.14; p ≤0.001), and annual relapse rate (ARR) (HR, 4.212; 95 % CI, 1.867–9.503; p = 0.001). Conclusion: Organ-specific and non-organ-specific autoantibodies are frequently observed in Korean patients with AQP4-ab-positive NMOSD. RF may be an independent predictor of high disability, along with age at onset and ARR.
Full Text
https://www.sciencedirect.com/science/article/pii/S0022510X24003502?via%3Dihub
DOI
10.1016/j.jns.2024.123215
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Ha Young(신하영) ORCID logo https://orcid.org/0000-0002-4408-8265
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/201172
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