Cited 0 times in

Quality of life in patients with myelin oligodendrocyte glycoprotein antibody associated disease compared to patients with AQP4-IgG positive neuromyelitis optica spectrum disorders: A Korean multicenter study

Authors
 Hyun Ji Lyou  ;  Ha Young Shin  ;  Hye Lim Lee  ;  Young Nam Kwon  ;  Seong-Il Oh  ;  Jeeyoung Oh  ;  Eun Bin Cho  ;  Sunyoung Kim  ;  Seol-Hee Baek  ;  Byung-Jo Kim  ;  Eunhee Sohn  ;  Jin Myoung Seok  ;  Ju-Hong Min  ;  Seung Woo Kim  ;  Byoung Joon Kim 
Citation
 MULTIPLE SCLEROSIS AND RELATED DISORDERS, Vol.91 : 105914, 2024-11 
Journal Title
MULTIPLE SCLEROSIS AND RELATED DISORDERS
ISSN
 2211-0348 
Issue Date
2024-11
MeSH
Adult ; Aquaporin 4* / immunology ; Autoantibodies* / blood ; Demyelinating Autoimmune Diseases, CNS / blood ; Demyelinating Autoimmune Diseases, CNS / immunology ; Demyelinating Autoimmune Diseases, CNS / physiopathology ; Depression / immunology ; Fatigue / etiology ; Fatigue / physiopathology ; Female ; Humans ; Immunoglobulin G* / blood ; Male ; Middle Aged ; Myelin-Oligodendrocyte Glycoprotein* / immunology ; Neuromyelitis Optica* / blood ; Neuromyelitis Optica* / immunology ; Neuromyelitis Optica* / physiopathology ; Quality of Life* ; Republic of Korea ; Young Adult
Keywords
Myelin oligodendrocyte glycoprotein antibody-associated disease ; Neuromyelitis optica spectrum disorder ; Psychological ; Quality of life ; Sleep
Abstract
Background: Little is known about the quality of life (QOL) of patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). We compared QOL and associated factors in patients with MOGAD and aquaporin4 IgG (AQP4-IgG) positive neuromyelitis optica spectrum disorder (NMOSD). Methods: This multicenter questionnaire study compared the QOL of 41 patients with MOGAD and 78 with AQP4-IgG positive NMOSD. Patients who were positive for AQP4-IgG or MOG antibodies were included. WHO Quality of Life Scale Brief Version was used to assess QOL in physical, psychological, social, and environmental domains. QOL, sleep quality, pain, fatigue, and depression were compared between the two groups. The factors associated with QOL in each group and the entire cohort were analyzed. Results: The proportion of patients with poor QOL was not significantly different between MOGAD (51.22 %) and AQP4-IgG positive NMOSD (58.97 %, p = 0.054). In the MOGAD group, the pain score (β=-1.032, p = 0.001) and depression score (β=-0.694, p = 0.007) were negatively associated with physical and psychological QOL, respectively. Sleep quality was negatively associated with physical (β=-1.506, p = 0.034) and psychological (β =-2.064, p = 0.033) QOL. When the entire cohort was analyzed, a positive MOG antibody was independently associated with worse psychological QOL (β=-8.998, p = 0.013) compared to positive AQP4-Ab after adjustment for sleep quality, depression, fatigue, and pain. Conclusions: The overall QOL of the patients of MOGAD was comparable to that of AQP4-IgG positive NMOSD. Patients with MOGAD were experiencing sleep disorder, fatigue, and depression at similar degrees to those of patients with AQP4-IgG positive NMOSD. Further consideration of sleep quality and psychological QOL is required to improve QOL in patients with MOGAD.
Full Text
https://linkinghub.elsevier.com/retrieve/pii/S2211-0348(24)00490-5
DOI
10.1016/j.msard.2024.105914
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Young Nam(권영남) ORCID logo https://orcid.org/0000-0002-3588-274X
Kim, Seung Woo(김승우) ORCID logo https://orcid.org/0000-0002-5621-0811
Shin, Ha Young(신하영) ORCID logo https://orcid.org/0000-0002-4408-8265
Lyou, Hyun Ji(유현지)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/200972
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links