In dental practice, the treatment and prevention of infections are crucial aspects of patient care, making the prescription of antimicrobials a common practice among dentists. Selecting the right antimicrobials is vital to ensure maximum efficacy in treating and preventing infections while minimizing the risk of adverse drug reactions. Often, antimicrobial prescriptions in dentistry are empirical, relying on the clinical characteristics of the infection and the suspected pathogens. Choosing the most appropriate antimicrobial for a patient involves considering the nature, course, and site of the infection, the patient's overall health, as well as the antimicrobial's toxicity, potential for allergic reactions, and risk of opportunistic infections. Adhering to evidence-based prescription guidelines is the most effective approach to antimicrobial selection. Such guidelines help dentists make informed decisions, ensuring that the chosen antimicrobial is both safe and effective for the specific clinical scenario. This paper aims to review these guidelines and provide a detailed analysis of the selection process for appropriate antimicrobials in dental practice. By doing so, it seeks to identify the best choices for managing and preventing infections, ultimately enhancing patient care and outcomes.