A Case Report of Lenacapavir Use in a Patient with Multidrug-Resistant HIV: The First Experience in Asia

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Authors: Yongseop Lee ; Ki Hyun Lee ; Jung Ah Lee ; Sang Min Ahn ; Min Han ; Jun Yong Choi

MeSH: Adult ; Anti-HIV Agents* / therapeutic use ; Asia ; CD4 Lymphocyte Count ; Drug Resistance, Multiple, Viral* ; HIV Infections* / drug therapy ; HIV Infections* / virology ; HIV-1* / drug effects ; Humans ; Male ; Viral Load* / drug effects

Keywords: HIV ; acquired immunodeficiency syndrome ; anti-retroviral agents ; drug resistance

Abstract: Lenacapavir is a novel, first-in-class, capsid inhibitor, which has been approved as an adjunctive therapy for multidrug-resistant human immunodeficiency virus (HIV)-1 virus in combination with optimized background regimen (OBR). Lenacapavir has demonstrated a significant decrease in viral load and high rate of virologic suppression in patients with multidrug-resistant HIV-1 infection with limited treatment options. Here, we report a case of 43-year-old male who was diagnosed with HIV-1 infection in 2005 but failed to achieve viral suppression due to multiclass resistance. After lenacapavir use with OBR, viral suppression was achieved, and recovery of CD4+ T-cell count was observed for 8 months. This case report shows the first lenacapavir experience in Asia in a heavily treatment-experienced HIV patient with limited treatment options.