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Differential effects of cholesterol levels on cognition according to body mass index in Parkinson's disease

Authors
 Seong Ho Jeong  ;  Seok Jong Chung  ;  Han Soo Yoo  ;  Jin Ho Jung  ;  Jong Sam Baik  ;  Young H Sohn  ;  Phil Hyu Lee 
Citation
 ALZHEIMERS RESEARCH & THERAPY, Vol.16(1) : 24, 2024-01 
Journal Title
ALZHEIMERS RESEARCH & THERAPY
Issue Date
2024-01
MeSH
Body Mass Index ; Cognition ; Cognitive Dysfunction* / diagnosis ; Dementia* / diagnosis ; Humans ; Neuropsychological Tests ; Obesity ; Parkinson Disease* / complications ; Parkinson Disease* / diagnostic imaging
Keywords
Body mass index ; Cholesterol ; Cognition ; Dementia ; Parkinson’s disease
Abstract
Background: Cholesterol is an essential component of the neuronal cell membrane and is crucial for neuronal function; however, the role of cholesterol levels in Parkinson's disease (PD) is debatable. This study investigated the complex relationship between total cholesterol (TC) levels, body mass index (BMI), and cognition in patients with PD.

Methods: This study included 321 drug-naïve patients with PD who underwent dopamine transporter (DAT) imaging and baseline neuropsychological tests. Multivariate linear regression and Cox regression models were used to investigate the effect of TC levels on the composite score of each cognitive domain and dementia conversion after adjusting for covariates, respectively. Interaction analyses were performed to examine the interaction effect between TC levels and BMI on baseline cognition and dementia conversion.

Results: TC levels and cognition showed no significant relationship after adjusting for potential confounders. A significant interaction effect between TC levels and BMI was observed in frontal/executive function and dementia conversion. Further analyses showed that TC levels were positively associated with frontal/executive function in the under-/normal weight group (β = 0.205, p = 0.013), whereas a negative relationship existed between TC levels and frontal/executive function in the obese group (β = - 0.213, p = 0.017). Cox regression analyses also showed the differential effects of TC levels on dementia conversion according to BMI (under-/normal weight group: hazard ratio [HR] = 0.550, p = 0.013; obese group: HR = 2.085, p = 0.014).

Conclusions: This study suggests a cross-over interaction between TC levels and BMI on cognitive symptoms in PD.
Files in This Item:
T202406074.pdf Download
DOI
10.1186/s13195-023-01326-2
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Yoo, Han Soo(유한수) ORCID logo https://orcid.org/0000-0001-7846-6271
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/200890
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