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Comparative analyses of post-infectious olfactory dysfunction between COVID-19 and non-COVID-19 cases

Authors
 Tae-Seong Eo  ;  Yeonsu Jeong  ;  Hyung-Ju Cho  ;  Min-Seok Rha  ;  Chang-Hoon Kim 
Citation
 SCIENTIFIC REPORTS, Vol.14(1) : 23511, 2024-10 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2024-10
MeSH
Adult ; Aged ; COVID-19* / complications ; Female ; Humans ; Male ; Middle Aged ; Olfaction Disorders* / etiology ; Olfaction Disorders* / virology ; SARS-CoV-2* / isolation & purification ; Smell / physiology ; Surveys and Questionnaires
Keywords
COVID-19 ; Olfaction disorders ; Olfactory training ; SARS-CoV-2 ; Smell
Abstract
To identify the differences between COVID-19-associated and non-COVID-19-associated olfactory dysfunction (OD), we analyzed demographic and clinical characteristics based on the causative virus (COVID versus non-COVID groups) in patients with post-infectious olfactory dysfunction (PIOD) who underwent the olfactory questionnaire and olfactory function test. Out of 169 patients with PIOD, 99 were diagnosed with COVID-19 (COVID group), while 70 were not (non-COVID group). The COVID group was younger and had a higher percentage of male patients as well as patients with parosmia than the non-COVID group. In the initial olfactory function tests, the TDI, discrimination and identification scores were significantly higher in the COVID group than in the non-COVID group. TDI scores were significantly increased in patients with PIOD after treatment, regardless of the group. The threshold score was significantly increased by 1.38 in the COVID group while the identification score was significantly increased by 2.67 in the non-COVID group. Patients with COVID-19-associated OD were younger in age, tended to be male, had a higher incidence of parosmia, and had better initial olfactory function test results compared to those with non-COVID-19-associated OD. Following treatment, odor detection threshold improved in the COVID group, whereas odor identification improved in the non-COVID group.
Files in This Item:
T202406037.pdf Download
DOI
10.1038/s41598-024-74629-5
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Hoon(김창훈) ORCID logo https://orcid.org/0000-0003-1238-6396
Rha, Min-Seok(나민석) ORCID logo https://orcid.org/0000-0003-1426-7534
Cho, Hyung Ju(조형주) ORCID logo https://orcid.org/0000-0002-2851-3225
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/200865
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