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Effect of physical activity on risk reduction of infective endocarditis among patients with diabetes: a nationwide cohort study

Authors
 Se Ju Lee  ;  Hee-Jung Kim  ;  Jinnam Kim  ;  Won Kyung Pyo  ;  Jung Ho Kim  ;  Jin Young Ahn  ;  Su Jin Jeong  ;  Jun Yong Choi  ;  Joon-Sup Yeom  ;  Kyungdo Han  ;  Nam Su Ku  ;  Seung Hyun Lee 
Citation
 SCIENTIFIC REPORTS, Vol.14(1) : 22254, 2024-09 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2024-09
MeSH
Adult ; Aged ; Cohort Studies ; Diabetes Mellitus / epidemiology ; Endocarditis* / epidemiology ; Endocarditis* / prevention & control ; Exercise* ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Proportional Hazards Models ; Risk Factors ; Risk Reduction Behavior
Keywords
Diabetes mellitus ; Exercise ; Infective endocarditis ; Physical activity ; Prevalence ; Prevention
Abstract
Patients with diabetes mellitus (DM) are at a higher risk of infectious diseases, and exercise is an important treatment modality for DM. Despite their susceptibility to infection in diabetic patients, the association between the amount of physical activity and the incidence of infective endocarditis (IE) is unclear. We attempted to demonstrate risk reduction by physical activity in diabetic patients with IE. From the National Health Insurance database, patients with DM were verified, and the incidence of IE was investigated. The level of physical activity was categorized into < 500, 500-999, 1,000-1,499, and ≥ 1,500 metabolic equivalent task (METs) minutes/week. Cox proportional hazard models were used to analyze the relationship between incident IE and physical activity. A total of 2,603,012 patients were included in this study. The incidence rate of IE was 10.06, 9.45, 7.78, and 8.84 in < 500, 500-999, 1,000-1,499, and ≥ 1,500 METs-minutes/week groups, respectively (100,000 person/year). A significant risk reduction of incident IE was observed in the 1,000-1499 and ≥ 1,500 METs-min/week groups compared to the < 500 METs-min/week group (Hazard ratio = 0.82, 95% confidence interval [0.690-0.976], HR = 0.831, 95% CI [0.704-0.981]). An analysis of a large national cohort database demonstrated that physical exercise reduced the risk of IE in patients with DM.
Files in This Item:
T202405994.pdf Download
DOI
10.1038/s41598-024-73993-6
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, Jung Ho(김정호) ORCID logo https://orcid.org/0000-0002-5033-3482
Ahn, Jin Young(안진영) ORCID logo https://orcid.org/0000-0002-3740-2826
Yeom, Joon Sup(염준섭) ORCID logo https://orcid.org/0000-0001-8940-7170
Lee, Seung Hyun(이승현) ORCID logo https://orcid.org/0000-0002-0311-6565
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Pyo, Won Kyung(표원경)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/200832
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