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Psychosocial barriers and facilitators for cascade genetic testing in hereditary breast and ovarian cancer: a scoping review

Authors
 Agani Afaya  ;  Sung-Won Kim  ;  Hyung Seok Park  ;  Myong Cheol Lim  ;  Mi Sook Jung  ;  Eun Ji Nam  ;  Ji Soo Park  ;  Joon Jeong  ;  Jai Min Ryu  ;  JiSun Kim  ;  Jihye Kim  ;  Minkyoung Kim  ;  Juhye Jin  ;  Jeehee Han  ;  Soo Yeon Kim  ;  Sun-Young Park  ;  Maria C Katapodi  ;  Sue Kim  ;  K-CASCADE consortium 
Citation
 FAMILIAL CANCER, Vol.23(2) : 121-132, 2024-06 
Journal Title
FAMILIAL CANCER
ISSN
 1389-9600 
Issue Date
2024-06
MeSH
Breast Neoplasms / diagnosis ; Breast Neoplasms / genetics ; Breast Neoplasms / psychology ; Family / psychology ; Female ; Genetic Predisposition to Disease* / psychology ; Genetic Testing* ; Hereditary Breast and Ovarian Cancer Syndrome / diagnosis ; Hereditary Breast and Ovarian Cancer Syndrome / genetics ; Hereditary Breast and Ovarian Cancer Syndrome / psychology ; Humans ; Ovarian Neoplasms / diagnosis ; Ovarian Neoplasms / genetics ; Ovarian Neoplasms / psychology
Keywords
BRCA1 ; BRCA2 ; Cancer ; Genetic testing ; HBOC ; Oncology ; Psychooncology
Abstract
Despite increased awareness and availability of genetic testing for hereditary breast and ovarian cancer (HBOC) syndrome for over 20 years, there is still significant underuse of cascade genetic testing among at-risk relatives. This scoping review synthesized evidence regarding psychosocial barriers and facilitators of family communication and/or uptake of cascade genetic testing in relatives from HBOC families. Search terms included 'hereditary breast and ovarian cancer' and 'cascade genetic testing' for studies published from 2012-2022. Through searching common databases, and manual search of references, 480 studies were identified after excluding duplications. Each article was reviewed by two researchers independently and 20 studies were included in the final analysis. CASP, RoBANS 2.0, RoB 2.0, and MMAT were used to assess the quality of included studies. A convergent data synthesis method was used to integrate evidence from quantitative and narrative data into categories and subcategories. Evidence points to 3 categories and 12 subcategories of psychosocial barriers and facilitators for cascade testing: (1) facilitators (belief in health protection and prevention; family closeness; decisional empowerment; family support, sense of responsibility; self-efficacy; supportive health professionals); (2) bidirectional concepts (information; perception of genetic/cancer consequences; negative emotions and attitude); and (3) barriers (negative reactions from family and negative family dynamics). Healthcare providers need to systematically evaluate these psychosocial factors, strengthen facilitators and alleviate barriers to promote informed decision-making for communication of genetic test results and uptake of genetic testing. Bidirectional factors merit special consideration and tailored approaches, as they can potentially have a positive or negative influence on family communication and uptake of genetic testing.
Full Text
https://link.springer.com/article/10.1007/s10689-024-00379-y
DOI
10.1007/s10689-024-00379-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
Yonsei Authors
Kim, Sue(김수) ORCID logo https://orcid.org/0000-0003-3785-2445
Nam, Eun Ji(남은지) ORCID logo https://orcid.org/0000-0003-0189-3560
Park, Ji Soo(박지수) ORCID logo https://orcid.org/0000-0002-0023-7740
Park, Hyung Seok(박형석) ORCID logo https://orcid.org/0000-0001-5322-6036
Jeong, Joon(정준) ORCID logo https://orcid.org/0000-0003-0397-0005
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/200779
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