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Bone Loss after Solid Organ Transplantation: A Review of Organ-Specific Considerations

Authors
 Kyoung Jin Kim  ;  Jeonghoon Ha  ;  Sang Wan Kim  ;  Jung-Eun Kim  ;  Sihoon Lee  ;  Han Seok Choi  ;  Namki Hong  ;  Sung Hye Kong  ;  Seong Hee Ahn  ;  So Young Park  ;  Ki-Hyun Baek 
Citation
 Endocrinology and Metabolism (대한내분비학회지), Vol.39(2) : 267-282, 2024-04 
Journal Title
Endocrinology and Metabolism(대한내분비학회지)
ISSN
 2093-596X 
Issue Date
2024-04
MeSH
Humans ; Immunosuppressive Agents / adverse effects ; Immunosuppressive Agents / therapeutic use ; Organ Transplantation* / adverse effects ; Osteoporosis* / etiology ; Postoperative Complications / etiology
Keywords
Bone loss ; Bone mineral density ; Fractures ; Osteoporosis ; Transplantation
Abstract
This review article investigates solid organ transplantation-induced osteoporosis, a critical yet often overlooked issue, emphasizing its significance in post-transplant care. The initial sections provide a comprehensive understanding of the prevalence and multifactorial pathogenesis of transplantation osteoporosis, including factors such as deteriorating post-transplantation health, hormonal changes, and the impact of immunosuppressive medications. Furthermore, the review is dedicated to organ-specific considerations in transplantation osteoporosis, with separate analyses for kidney, liver, heart, and lung transplantations. Each section elucidates the unique challenges and management strategies pertinent to transplantation osteoporosis in relation to each organ type, highlighting the necessity of an organ-specific approach to fully understand the diverse manifestations and implications of transplantation osteoporosis. This review underscores the importance of this topic in transplant medicine, aiming to enhance awareness and knowledge among clinicians and researchers. By comprehensively examining transplantation osteoporosis, this study contributes to the development of improved management and care strategies, ultimately leading to improved patient outcomes in this vulnerable group. This detailed review serves as an essential resource for those involved in the complex multidisciplinary care of transplant recipients.
DOI
10.3803/EnM.2024.1939
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Hong, Nam Ki(홍남기) ORCID logo https://orcid.org/0000-0002-8246-1956
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/200771
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