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Resorbable Microspheres versus Trisacryl Gelatin Microspheres for Uterine Artery Embolization: A Randomized Controlled Trial

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dc.contributor.author권준호-
dc.contributor.author김경민-
dc.contributor.author김동규-
dc.contributor.author김만득-
dc.contributor.author김소연-
dc.contributor.author문성모-
dc.contributor.author박주일-
dc.contributor.author원종윤-
dc.contributor.author한기창-
dc.contributor.author김형철-
dc.contributor.author최진영-
dc.date.accessioned2024-12-06T02:05:45Z-
dc.date.available2024-12-06T02:05:45Z-
dc.date.issued2024-09-
dc.identifier.issn0033-8419-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/200687-
dc.description.abstractBackground There are insufficient data comparing resorbable microspheres (RMs) with permanent trisacryl gelatin microspheres (TAGMs) for uterine artery embolization (UAE). Purpose To compare therapeutic efficacy and clinical outcomes in participants with symptomatic fibroids after UAE with RMs or TAGMs. Materials and Methods This randomized controlled trial included participants undergoing UAE for symptomatic fibroids at a single institution (from May 2021 to May 2023). Participants were randomized one-to-one to undergo UAE with either RMs or TAGMs. Numeric rating scale pain scores and cumulative fentanyl consumption were assessed for 24 hours after undergoing UAE. Anti-Mullerian hormone was measured to assess effects of UAE on ovarian function. MRI was performed before and 3 months after UAE to evaluate fibroid necrosis and uterine artery recanalization. Repeated variables such as pain were analyzed using Mann-Whitney U test with post hoc Bonferroni correction. Results Sixty female participants (mean age, 45.7 years ± 3.6 [SD]) completed the study, with 30 in each group. No evidence of a difference in pain scores was observed between groups (P > .99). Moreover, there was no evidence of a difference in the total fentanyl consumption at 24 hours after UAE between groups (median: RMs, 423 [IQR, 330-530] vs TAGMs, 562 [IQR, 437-780]; P = .15). Serum anti-Mullerian hormone 3 months after UAE showed no evidence of a difference between groups (RMs vs TAGMs, 0.71 ng/mL ± 0.73 vs 0.49 ng/mL ± 0.45, respectively; P = .09). No evidence of a difference in the rate of complete necrosis of the dominant fibroid was observed between groups (97% [29 of 30] for both groups; P > .99). The rate of uterine artery recanalization was higher in RM versus TAGM groups (70% [21 of 30] vs 17% [five of 30], respectively; P < .001). Conclusion UAE with RMs, compared with UAE with TAGMs, showed no evidence of a difference in terms of therapeutic effectiveness or postprocedural pain scores in participants with symptomatic fibroids. Clinical trial registration no. NCT05086770-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherRadiological Society of North America-
dc.relation.isPartOfRADIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAcrylic Resins* / therapeutic use-
dc.subject.MESHAdult-
dc.subject.MESHFemale-
dc.subject.MESHGelatin* / therapeutic use-
dc.subject.MESHHumans-
dc.subject.MESHLeiomyoma* / diagnostic imaging-
dc.subject.MESHLeiomyoma* / therapy-
dc.subject.MESHMicrospheres-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPain Measurement-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHUterine Artery Embolization* / methods-
dc.subject.MESHUterine Neoplasms / diagnostic imaging-
dc.subject.MESHUterine Neoplasms / therapy-
dc.titleResorbable Microspheres versus Trisacryl Gelatin Microspheres for Uterine Artery Embolization: A Randomized Controlled Trial-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorKichang Han-
dc.contributor.googleauthorSo Yeon Kim-
dc.contributor.googleauthorMan-Deuk Kim-
dc.contributor.googleauthorJoon Ho Kwon-
dc.contributor.googleauthorGyoung Min Kim-
dc.contributor.googleauthorSungmo Moon-
dc.contributor.googleauthorJuil Park-
dc.contributor.googleauthorHyung Cheol Kim-
dc.contributor.googleauthorJong Yun Won-
dc.contributor.googleauthorTurki Mohammed A Dhahi-
dc.contributor.googleauthorJinyoung Choi-
dc.contributor.googleauthorDong Kyu Kim-
dc.contributor.googleauthorJinho Yang-
dc.contributor.googleauthorHye Jung Shin-
dc.identifier.doi10.1148/radiol.231525-
dc.contributor.localIdA05085-
dc.contributor.localIdA00296-
dc.contributor.localIdA05609-
dc.contributor.localIdA00420-
dc.contributor.localIdA00616-
dc.contributor.localIdA06146-
dc.contributor.localIdA06365-
dc.contributor.localIdA02443-
dc.contributor.localIdA05062-
dc.relation.journalcodeJ02596-
dc.identifier.eissn1527-1315-
dc.identifier.pmid39254451-
dc.identifier.urlhttps://pubs.rsna.org/doi/10.1148/radiol.231525-
dc.contributor.alternativeNameKwon, Joon Ho-
dc.contributor.affiliatedAuthor권준호-
dc.contributor.affiliatedAuthor김경민-
dc.contributor.affiliatedAuthor김동규-
dc.contributor.affiliatedAuthor김만득-
dc.contributor.affiliatedAuthor김소연-
dc.contributor.affiliatedAuthor문성모-
dc.contributor.affiliatedAuthor박주일-
dc.contributor.affiliatedAuthor원종윤-
dc.contributor.affiliatedAuthor한기창-
dc.citation.volume312-
dc.citation.number3-
dc.citation.startPagee231525-
dc.identifier.bibliographicCitationRADIOLOGY, Vol.312(3) : e231525, 2024-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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