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Generation of a human induced pluripotent stem cell line (YUCMi020-A) from peripheral blood mononuclear cells derived from a female with the Jr(a-) blood type

Authors
 Youn Keong Cho  ;  Hyun-Kyung Kim  ;  Eun Jung Suh  ;  Hyun Ok Kim  ;  Sinyoung Kim 
Citation
 STEM CELL RESEARCH, Vol.77 : 103434, 2024-06 
Journal Title
STEM CELL RESEARCH
ISSN
 1873-5061 
Issue Date
2024-06
MeSH
ATP Binding Cassette Transporter, Subfamily G, Member 2 / genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 2 / metabolism ; Blood Group Antigens / metabolism ; Cell Differentiation ; Cell Line ; Female ; Humans ; Induced Pluripotent Stem Cells* / cytology ; Induced Pluripotent Stem Cells* / metabolism ; Leukocytes, Mononuclear* / cytology ; Leukocytes, Mononuclear* / metabolism
Abstract
The Jra antigen, the only antigen within the JR blood group system, is a high-prevalence red blood cell (RBC) antigen found in over 99 % of the global population. An induced pluripotent stem cell line (YUCMi020-A) was generated from peripheral blood drawn from a Jr(a−) phenotype individual, who was homozygous for a null mutation of ABCG2*01N.01 (rs72552713, c.376C>T; p.Gln126*). The generated line exhibited pluripotent characteristics and no chromosomal aberrations. This cell line will serve as a cell source, enabling us to produce RBCs with the Jr(a−) phenotype in vitro, which can be used for transfusing individuals with anti-Jra antibodies. © 2024
Files in This Item:
T202403290.pdf Download
DOI
10.1016/j.scr.2024.103434
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sin Young(김신영) ORCID logo https://orcid.org/0000-0002-2609-8945
Kim, Hyun Ok(김현옥) ORCID logo https://orcid.org/0000-0002-4964-1963
Cho, Youn Keong(조윤경) ORCID logo https://orcid.org/0000-0002-7922-0473
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/199819
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