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A randomized controlled study to assess the effect of mosapride citrate on intestinal recovery following gastrectomy

 Shiyeol Jun  ;  Seyeol Oh  ;  Ji Eun Jung  ;  In Gyu Kwon  ;  Sung Hoon Noh 
 SCIENTIFIC REPORTS, Vol.14(1) : 7030, 2024-03 
Journal Title
Issue Date
Benzamides* / therapeutic use ; Flatulence ; Gastrectomy* / adverse effects ; Gastrectomy* / methods ; Humans ; Laparoscopy / methods ; Length of Stay ; Morpholines* / therapeutic use ; Postoperative Complications / prevention & control ; Prospective Studies ; Stomach Neoplasms* / surgery ; Treatment Outcome
The enhanced recovery after surgery (ERAS) protocol, including prokinetic medications, is commonly used to prevent postoperative ileus. Prospective studies evaluating the effectiveness of mosapride citrate, a prokinetic 5-hydroxytryptamine 4 receptor agonist, in patients undergoing gastrectomy within the ERAS framework are lacking. This double-blind randomized trial included patients who were scheduled for laparoscopic or robotic gastrectomy for gastric cancer. Participants were randomly assigned to either a control (placebo) or experimental (mosapride citrate) group, with drugs administered on postoperative days 1–5. Bowel motility was evaluated based on bowel transit time measured using radiopaque markers, first-flatus time, and amount of food intake. No significant differences were observed in baseline characteristics between the two groups. On postoperative day 3, no significant difference was observed in the number of radiopaque markers visible in the colon between the groups. All factors associated with bowel recovery, including the time of first flatus, length of hospital stay, amount of food intake, and severity of abdominal discomfort, were similar between the two groups. Mosapride citrate does not benefit the recovery of intestinal motility after minimally invasive gastrectomy in patients with gastric cancer. Therefore, routine postoperative use of mosapride citrate is not recommended in such patients. © The Author(s) 2024.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, In Gyu(권인규) ORCID logo https://orcid.org/0000-0002-1489-467X
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Oh, Seyeol(오세열)
Jun, Shiyeol(전시열)
Jung, Ji Eun(정지은)
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