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Trends, clinical characteristics, antimicrobial susceptibility patterns, and outcomes of Campylobacter bacteraemia: a multicentre retrospective study

Authors
 Yae Jee Baek  ;  Je Eun Song  ;  Eun Jin Kim  ;  Heun Choi  ;  Yujin Sohn  ;  Yong Duk Jeon  ;  Eun Hwa Lee  ;  Jin Young Ahn  ;  Su Jin Jeong  ;  Nam Su Ku  ;  Jun Yong Choi  ;  Joon-Sup Yeom  ;  Young Goo Song  ;  Jung Ho Kim 
Citation
 INFECTION, Vol.52(3) : 857-864, 2024-06 
Journal Title
INFECTION
ISSN
 0300-8126 
Issue Date
2024-06
MeSH
Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents* / pharmacology ; Anti-Bacterial Agents* / therapeutic use ; Bacteremia* / drug therapy ; Bacteremia* / epidemiology ; Bacteremia* / microbiology ; Bacteremia* / mortality ; Campylobacter / drug effects ; Campylobacter Infections* / drug therapy ; Campylobacter Infections* / epidemiology ; Campylobacter Infections* / microbiology ; Campylobacter Infections* / mortality ; Campylobacter jejuni / drug effects ; Drug Resistance, Bacterial ; Female ; Hospital Mortality ; Humans ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Retrospective Studies ; Risk Factors ; Young Adult
Keywords
Bacteraemia ; Campylobacter infection ; One health ; Risk factors ; Trends
Abstract
Purpose: We aimed to explore the clinical characteristics of Campylobacter bacteraemia and identify the trends, risk factors for mortality, and antimicrobial susceptibility patterns from clinical samples.

Methods: This retrospective cohort study included patients confirmed to have Campylobacter bacteraemia from seven hospitals between January 2010 and June 2021. Data on demographics and underlying history, clinical manifestation, and antimicrobial susceptibility patterns were collected and analyzed. Annual cases of Campylobacter enteritis were extracted from a public database.

Results: A total of 108 patients were included, and five species were isolated. Campylobacter jejuni accounted for 54 (50.0%) cases and 17 (16%) patients had no symptoms other than fever. In-hospital mortality occurred in 14 (13.0%) patients. C. jejuni bacteraemia was associated with lower mortality compared to non-C. jejuni bacteraemia. Underlying cancer and septic shock were the significant factors associated with in-hospital mortality. Quinolone resistance was high (59%), whereas only 4% of isolates exhibited macrolide resistance. There has been a significant increase in the number of Campylobacter enteritis cases, which was strongly correlated with the number of Campylobacter bacteraemia cases (Pearson's coefficient: 0.953; p < 0.0001).

Conclusion: The notably increasing incidence of Campylobacter bacteraemia and antibiotic resistance patterns can challenge the treatment, necessitating collective efforts of national surveillance and networks by many departments.
Full Text
https://link.springer.com/article/10.1007/s15010-023-02118-4
DOI
10.1007/s15010-023-02118-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, Jung Ho(김정호) ORCID logo https://orcid.org/0000-0002-5033-3482
Baek, Yae Jee(백예지)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Ahn, Jin Young(안진영) ORCID logo https://orcid.org/0000-0002-3740-2826
Yeom, Joon Sup(염준섭) ORCID logo https://orcid.org/0000-0001-8940-7170
Lee, Eun Hwa(이은화)
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/199757
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