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Triglyceride-glucose-waist circumference index predicts the incidence of cardiovascular disease in Korean populations: competing risk analysis of an 18-year prospective study
DC Field | Value | Language |
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dc.contributor.author | 이혜선 | - |
dc.contributor.author | 안성호 | - |
dc.date.accessioned | 2024-06-14T02:53:11Z | - |
dc.date.available | 2024-06-14T02:53:11Z | - |
dc.date.issued | 2024-04 | - |
dc.identifier.issn | 0949-2321 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/199750 | - |
dc.description.abstract | Background: The triglyceride and glucose-waist circumference (TyG-WC) index demonstrated a strong association with insulin resistance, especially in Asian population. However, evidence on the association between TyG-WC index and the occurrence of cardiovascular disease (CVD) is limited. This study aimed to verify association between the TyG-WC index and the occurrence of CVD by considering all-cause mortality as a competing risk. Methods: The study included 7482 participants divided into four groups based on the TyG-WC index quartiles. Kaplan–Meier curves illustrated cumulative incidence rates of CVD and all-cause mortality during the follow-up period. Log-rank tests determined group differences. The Cox proportional hazard spline curve demonstrates the dose-dependent relationship between the TyG-WC index and incident CVD. Modified Cox regression (Fine and Gray) estimated hazard ratios (HRs) with 95% CIs for incident CVD, treating death as a competing risk. Death event after incident CVD was excluded from the death count. Results: During the median 15.94 year of follow-up period, a total of 691 (9.24%) new-onset CVD cases and 562 (7.51%) all-cause mortality cases were confirmed. Cox proportional hazard spline curves suggested that TyG-WC index exhibited a dose-dependent positive correlation with incident CVD. The cumulative incidence rate of CVD was significantly higher in the groups with higher TyG-WC index quartiles in Kaplan–Meier curves. The adjusted HR (95% CI) for incident CVD in Q2–Q4, compared with Q1, was 1.47 (1.12–1.93), 1.91 (1.44–2.54) and 2.24 (1.63–3.07), respectively. There was no significant association between TyG-WC index and all-cause mortality. Specifically, angina and stroke were significantly associated with the TyG-WC index, in contrast to myocardial infarction and peripheral artery disease. Conclusions: The TyG-WC index was positively associated with incident CVD even considering all-cause mortality as a competing risk. Therefore, TyG-WC index may be a valuable marker for predicting the occurrence of CVD. © The Author(s) 2024. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF MEDICAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Biomarkers | - |
dc.subject.MESH | Blood Glucose | - |
dc.subject.MESH | Cardiovascular Diseases* / epidemiology | - |
dc.subject.MESH | Glucose | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Republic of Korea / epidemiology | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Triglycerides | - |
dc.subject.MESH | Waist Circumference | - |
dc.title | Triglyceride-glucose-waist circumference index predicts the incidence of cardiovascular disease in Korean populations: competing risk analysis of an 18-year prospective study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Sung Ho Ahn | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Jun-Hyuk Lee | - |
dc.identifier.doi | 10.1186/s40001-024-01820-9 | - |
dc.contributor.localId | A03312 | - |
dc.contributor.localId | A06617 | - |
dc.relation.journalcode | J04514 | - |
dc.identifier.eissn | 2047-783X | - |
dc.identifier.pmid | 38566247 | - |
dc.subject.keyword | Cardiovascular disease | - |
dc.subject.keyword | Cohort | - |
dc.subject.keyword | Insulin resistance | - |
dc.subject.keyword | Mortality | - |
dc.subject.keyword | Triglyceride and glucose-waist circumference index | - |
dc.contributor.alternativeName | Lee, Hye Sun | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.contributor.affiliatedAuthor | 안성호 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 214 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF MEDICAL RESEARCH, Vol.29(1) : 214, 2024-04 | - |
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