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Predictors for False-Negative Interferon-Gamma Release Assay Results in Hemodialysis Patients with Latent Tuberculosis Infection

Authors
 Heechul Park  ;  Yun-Jeong Kang  ;  Ye Na Kim  ;  Sung-Bae Park  ;  Jaewon Lim  ;  Ji Young Park  ;  Young Ae Kang  ;  Hyejon Lee  ;  Jungho Kim  ;  Sunghyun Kim 
Citation
 DIAGNOSTICS, Vol.13(1) : 88, 2023-01 
Journal Title
DIAGNOSTICS
Issue Date
2023-01
Keywords
IGRAs ; LTBI ; QFT-GIT ; TB ; hemodialysis patients
Abstract
The present study aimed to clinically evaluate the effect of T-cell dysfunction in hemodialysis (HD) patients with latent tuberculosis (TB) infection (LTBI) who were false-negatives in the QuantiFERON-TB Gold In-Tube (QFT-GIT) test. Whole blood samples from a total of 20 active TB patients, 83 HD patients, and 52 healthy individuals were collected, and the QFT-GIT test was used for measuring Mycobacterium tuberculosis (MTB)-specific interferon gamma (IFN-gamma) level. The positive rate of the IFN-gamma release assays (IGRAs) in HD patients was lower than the negative rate. The mean value of MTB-specific IFN-gamma level, which determines the positive rate of the IGRA test, was highest in active TB, followed by HD patients and healthy individuals. Among HD patients, phytohemagglutinin A (PHA)-stimulated IFN-gamma levels of approximately 40% were 10.00 IU/mL or less. However, there was no low level of PHA-stimulated IFN-gamma in the healthy individuals. This reveals that T-cell function in HD patients was reduced compared to healthy individuals, which leads to the possibility that QFT-GIT results in HD patients are false-negative. The clinical manifestations of TB in patients on HD are quite non-specific, making timely diagnosis difficult and delaying the initiation of curative treatment, delay being a major determinant of outcome.
Files in This Item:
T992023420.pdf Download
DOI
10.3390/diagnostics13010088
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Young Ae(강영애) ORCID logo https://orcid.org/0000-0002-7783-5271
Lee, Hyejon(이혜존) ORCID logo https://orcid.org/0000-0001-8207-537X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/199684
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