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Preclinical Research on Focused Ultrasound-Mediated Blood-Brain Barrier Opening for Neurological Disorders: A Review

Authors
 Chanho Kong  ;  Won Seok Chang 
Citation
 NEUROLOGY INTERNATIONAL, Vol.15(1) : 285-300, 2023-02 
Journal Title
NEUROLOGY INTERNATIONAL
ISSN
 2035-8385 
Issue Date
2023-02
Keywords
blood–brain barrier ; drug delivery ; focused ultrasound ; neurological disorders
Abstract
Several therapeutic agents for neurological disorders are usually not delivered to the brain owing to the presence of the blood-brain barrier (BBB), a special structure present in the central nervous system (CNS). Focused ultrasound (FUS) combined with microbubbles can reversibly and temporarily open the BBB, enabling the application of various therapeutic agents in patients with neurological disorders. In the past 20 years, many preclinical studies on drug delivery through FUS-mediated BBB opening have been conducted, and the use of this method in clinical applications has recently gained popularity. As the clinical application of FUS-mediated BBB opening expands, it is crucial to understand the molecular and cellular effects of FUS-induced microenvironmental changes in the brain so that the efficacy of treatment can be ensured, and new treatment strategies established. This review describes the latest research trends in FUS-mediated BBB opening, including the biological effects and applications in representative neurological disorders, and suggests future directions.
Files in This Item:
T992023381.pdf Download
DOI
10.3390/neurolint15010018
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kong, Chanho(공찬호)
Chang, Won Seok(장원석) ORCID logo https://orcid.org/0000-0003-3145-4016
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/199646
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