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Preclinical Research on Focused Ultrasound-Mediated Blood-Brain Barrier Opening for Neurological Disorders: A Review

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dc.contributor.author공찬호-
dc.contributor.author장원석-
dc.date.accessioned2024-05-30T07:13:01Z-
dc.date.available2024-05-30T07:13:01Z-
dc.date.issued2023-02-
dc.identifier.issn2035-8385-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/199646-
dc.description.abstractSeveral therapeutic agents for neurological disorders are usually not delivered to the brain owing to the presence of the blood-brain barrier (BBB), a special structure present in the central nervous system (CNS). Focused ultrasound (FUS) combined with microbubbles can reversibly and temporarily open the BBB, enabling the application of various therapeutic agents in patients with neurological disorders. In the past 20 years, many preclinical studies on drug delivery through FUS-mediated BBB opening have been conducted, and the use of this method in clinical applications has recently gained popularity. As the clinical application of FUS-mediated BBB opening expands, it is crucial to understand the molecular and cellular effects of FUS-induced microenvironmental changes in the brain so that the efficacy of treatment can be ensured, and new treatment strategies established. This review describes the latest research trends in FUS-mediated BBB opening, including the biological effects and applications in representative neurological disorders, and suggests future directions.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfNEUROLOGY INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePreclinical Research on Focused Ultrasound-Mediated Blood-Brain Barrier Opening for Neurological Disorders: A Review-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학교실)-
dc.contributor.googleauthorChanho Kong-
dc.contributor.googleauthorWon Seok Chang-
dc.identifier.doi10.3390/neurolint15010018-
dc.contributor.localIdA05816-
dc.contributor.localIdA03454-
dc.relation.journalcodeJ04603-
dc.identifier.eissn2035-8377-
dc.identifier.pmid36810473-
dc.subject.keywordblood–brain barrier-
dc.subject.keyworddrug delivery-
dc.subject.keywordfocused ultrasound-
dc.subject.keywordneurological disorders-
dc.contributor.alternativeNameKong, Chanho-
dc.contributor.affiliatedAuthor공찬호-
dc.contributor.affiliatedAuthor장원석-
dc.citation.volume15-
dc.citation.number1-
dc.citation.startPage285-
dc.citation.endPage300-
dc.identifier.bibliographicCitationNEUROLOGY INTERNATIONAL, Vol.15(1) : 285-300, 2023-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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