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Evaluation and Monitoring of the Natural Toxin Ptaquiloside in Bracken Fern, Meat, and Dairy Products
DC Field | Value | Language |
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dc.date.accessioned | 2024-05-30T07:11:14Z | - |
dc.date.available | 2024-05-30T07:11:14Z | - |
dc.date.issued | 2023-03 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/199619 | - |
dc.description.abstract | Ptaquiloside, a naturally occurring cancer-causing substance in bracken fern, has been detected in the meat and milk of cows fed a diet containing bracken fern. A rapid and sensitive method for the quantitative analysis of ptaquiloside in bracken fern, meat, and dairy products was developed using the QuEChERS method and liquid chromatography-tandem mass spectrometry. The method was validated according to the Association of Official Analytical Chemists guidelines and met the criteria. A single matrix-matched calibration method with bracken fern has been proposed, which is a novel strategy that uses one calibration for multiple matrices. The calibration curve ranged from 0.1 to 50 mu g/kg and showed good linearity (r(2) > 0.99). The limits of detection and quantification were 0.03 and 0.09 mu g/kg, respectively. The intraday and interday accuracies were 83.5-98.5%, and the precision was <9.0%. This method was used for the monitoring and exposure assessment of ptaquiloside in all routes of exposure. A total of 0.1 mu g/kg of ptaquiloside was detected in free-range beef, and the daily dietary exposure of South Koreans to ptaquiloside was estimated at up to 3.0 x 10(-5) mu g/kg b.w./day. The significance of this study is to evaluate commercially available products in which ptaquiloside may be present, to monitor consumer safety. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | TOXINS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cattle | - |
dc.subject.MESH | Meat / analysis | - |
dc.subject.MESH | Milk / chemistry | - |
dc.subject.MESH | Pteridium* | - |
dc.subject.MESH | Sesquiterpenes* / analysis | - |
dc.title | Evaluation and Monitoring of the Natural Toxin Ptaquiloside in Bracken Fern, Meat, and Dairy Products | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Others | - |
dc.contributor.googleauthor | Hana Park | - |
dc.contributor.googleauthor | Yoeseph Cho | - |
dc.contributor.googleauthor | JiEun Lee | - |
dc.contributor.googleauthor | Kang Mi Lee | - |
dc.contributor.googleauthor | Ho Jun Kim | - |
dc.contributor.googleauthor | Jaeick Lee | - |
dc.contributor.googleauthor | Yong-Sun Bahn | - |
dc.contributor.googleauthor | Junghyun Son | - |
dc.identifier.doi | 10.3390/toxins15030231 | - |
dc.relation.journalcode | J02746 | - |
dc.identifier.eissn | 2072-6651 | - |
dc.identifier.pmid | 36977122 | - |
dc.subject.keyword | LC–MS/MS | - |
dc.subject.keyword | QuEChERS (quick, easy, cheap, effective, rugged and safe) | - |
dc.subject.keyword | bracken fern | - |
dc.subject.keyword | exposure assessment | - |
dc.subject.keyword | method validation | - |
dc.subject.keyword | monitoring | - |
dc.subject.keyword | ptaquiloside | - |
dc.citation.volume | 15 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 231 | - |
dc.identifier.bibliographicCitation | TOXINS, Vol.15(3) : 231, 2023-03 | - |
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