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Air pollution is associated with faster cognitive decline in Alzheimer's disease

Authors
 Young-Gun Lee  ;  Seon-Jin Yoon  ;  So Hoon Yoon  ;  Sung Woo Kang  ;  Seun Jeon  ;  Minseok Kim  ;  Dong Ah Shin  ;  Chung Mo Nam  ;  Byoung Seok Ye 
Citation
 ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, Vol.10(6) : 964-973, 2023-06 
Journal Title
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY(Ann Clin Transl Neurol)
Issue Date
2023-06
MeSH
Air Pollutants* / adverse effects ; Air Pollutants* / analysis ; Air Pollution* / adverse effects ; Alzheimer Disease* / etiology ; Cognitive Dysfunction* / etiology ; Humans ; Longitudinal Studies ; Nitrogen Dioxide / adverse effects ; Particulate Matter / adverse effects
Abstract
ObjectiveAlthough chronic exposure to air pollution is associated with an increased risk of dementia in normal elderlies, the effect of chronic exposure to air pollution on the rates of cognitive decline in Alzheimer's disease (AD) has not been elucidated. MethodsIn this longitudinal study, a total of 269 patients with mild cognitive impairment or early dementia due to AD with the evidence of brain beta-amyloid deposition were followed-up for a mean period of 4 years. Five-year normalized hourly cumulative exposure value of each air pollutant, such as carbon monoxide (CO), nitrogen dioxide (NO2), sulfur dioxide (SO2), and particulate matter (PM2.5 and PM10), was computed based on nationwide air pollution database. The effects of chronic exposure to air pollution on longitudinal cognitive decline rate were evaluated using linear mixed models. ResultsHigher chronic exposure to SO2 was associated with a faster decline in memory score, whereas chronic exposure to CO, NO2, and PM10 were not associated with the rate of cognitive decline. Higher chronic exposure to PM2.5 was associated with a faster decline in visuospatial score in apolipoprotein E epsilon 4 carriers. These effects remained significant even after adjusting for potential confounders. InterpretationOur findings suggest that chronic exposure to SO2 and PM2.5 is associated with faster clinical progression in AD.
Files in This Item:
T992023282.pdf Download
DOI
10.1002/acn3.51779
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Sung Woo(강성우)
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Shin, Dong Ah(신동아) ORCID logo https://orcid.org/0000-0002-5225-4083
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Yoon, Seon Jin(윤선진) ORCID logo https://orcid.org/0000-0002-3255-5081
Yoon, So Hoon(윤소훈)
Lee, Young-Gun(이영건)
Jeon, Seun(전세운) ORCID logo https://orcid.org/0000-0003-2817-3352
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/199547
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