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Diagnostic Strategies for Brain Doping in an Animal Model via Quantitative Analysis of Neurochemicals

Authors
 Yoeseph Cho  ;  Seongeun Jeon  ;  Yejin Lee  ;  Hana Park  ;  Yinglan Xu  ;  Mijin Jeon  ;  Sunmi Jung  ;  Minyoung Kim  ;  Ahlim Chin  ;  Sang Sun Yoon  ;  Junghyun Son 
Citation
 SEPARATIONS, Vol.10(7) : 413, 2023-07 
Journal Title
 SEPARATIONS 
Issue Date
2023-07
Abstract
Brain doping is a novel form of doping that involves stimulating specific brain regions to enhance sports performance. However, to the best of our knowledge, there is currently no established provision or detection method for it. As brain stimulation ultimately induces alterations in neurochemical concentrations, this study aimed to develop a diagnostic strategy for brain doping. We successfully developed and validated a sensitive simultaneous analysis method for 23 neurochemicals present in urine. Simple derivatization was employed to overcome ionization efficiency, enabling the effective detection of all the target compounds within 5 min. Additionally, we developed an animal model system using rats to replicate brain-doping scenarios and establish a diagnostic strategy. Behavior tests confirmed improved sports performance in the brain stimulation group. By examining changes in the distribution patterns of the target substances in urine samples, we observed that neurochemicals could be used as potential biomarkers for brain-doping diagnosis. The developed method allows the effective simultaneous analysis of multiple neurochemicals in biological samples and is expected to have various applications, including doping control. Thus, changes in the distribution pattern of neurochemicals could serve as a basis for brain-doping diagnosis.
Files in This Item:
T992023211.pdf Download
DOI
10.3390/separations10070413
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Sang Sun(윤상선) ORCID logo https://orcid.org/0000-0003-2979-365X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/199476
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