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A multi-channel collagen conduit with aligned Schwann cells and endothelial cells for enhanced neuronal regeneration in spinal cord injury

Authors
 Hye Yeong Lee  ;  Seo Hyun Moon  ;  Donggu Kang  ;  Eunjeong Choi  ;  Gi Hoon Yang  ;  Keung Nyun Kim  ;  Joo Yun Won  ;  Seong Yi 
Citation
 BIOMATERIALS SCIENCE, Vol.11(24) : 7884-7896, 2023-12 
Journal Title
BIOMATERIALS SCIENCE
ISSN
 2047-4830 
Issue Date
2023-12
MeSH
Collagen ; Endothelial Cells ; Humans ; Nerve Regeneration* ; Schwann Cells ; Spinal Cord ; Spinal Cord Injuries* / therapy
Abstract
Traumatic spinal cord injury (SCI) leads to Wallerian degeneration and the accompanying disruption of vasculature leads to ischemia, which damages motor and sensory function. Therefore, understanding the biological environment during regeneration is essential to promote neuronal regeneration and overcome this phenomenon. The band of Büngner is a structure of an aligned Schwann cell (SC) band that guides axon elongation providing a natural recovery environment. During axon elongation, SCs promote axon elongation while migrating along neovessels (endothelial cells [ECs]). To model this, we used extrusion 3D bioprinting to develop a multi-channel conduit (MCC) using collagen for the matrix region and sacrificial alginate to make the channel. The MCC was fabricated with a structure in which SCs and ECs were longitudinally aligned to mimic the sophisticated recovering SCI conditions. Also, we produced an MCC with different numbers of channels. The aligned SCs and ECs in the 9-channel conduit (9MCC-SE) were more biocompatible and led to more proliferation than the 5-channel conduit (5MCC-SE) in vitro. Also, the 9MCC-SE resulted in a greater healing effect than the 5MCC-SE with respect to neuronal regeneration, remyelination, inflammation, and angiogenesis in vivo. The above tissue recovery results led to motor function repair. Our results show that our 9MCC-SE model represents a new therapeutic strategy for SCI.
Full Text
https://pubs.rsc.org/en/content/articlelanding/2023/bm/d3bm01152f
DOI
10.1039/d3bm01152f
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Keung Nyun(김긍년)
Yi, Seong(이성)
Lee, Hye Yeong(이혜영) ORCID logo https://orcid.org/0000-0002-2935-4975
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/199297
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