0 78

Cited 0 times in

A multi-channel collagen conduit with aligned Schwann cells and endothelial cells for enhanced neuronal regeneration in spinal cord injury

DC Field Value Language
dc.contributor.author김긍년-
dc.contributor.author이성-
dc.contributor.author이혜영-
dc.date.accessioned2024-05-30T06:42:18Z-
dc.date.available2024-05-30T06:42:18Z-
dc.date.issued2023-12-
dc.identifier.issn2047-4830-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/199297-
dc.description.abstractTraumatic spinal cord injury (SCI) leads to Wallerian degeneration and the accompanying disruption of vasculature leads to ischemia, which damages motor and sensory function. Therefore, understanding the biological environment during regeneration is essential to promote neuronal regeneration and overcome this phenomenon. The band of Büngner is a structure of an aligned Schwann cell (SC) band that guides axon elongation providing a natural recovery environment. During axon elongation, SCs promote axon elongation while migrating along neovessels (endothelial cells [ECs]). To model this, we used extrusion 3D bioprinting to develop a multi-channel conduit (MCC) using collagen for the matrix region and sacrificial alginate to make the channel. The MCC was fabricated with a structure in which SCs and ECs were longitudinally aligned to mimic the sophisticated recovering SCI conditions. Also, we produced an MCC with different numbers of channels. The aligned SCs and ECs in the 9-channel conduit (9MCC-SE) were more biocompatible and led to more proliferation than the 5-channel conduit (5MCC-SE) in vitro. Also, the 9MCC-SE resulted in a greater healing effect than the 5MCC-SE with respect to neuronal regeneration, remyelination, inflammation, and angiogenesis in vivo. The above tissue recovery results led to motor function repair. Our results show that our 9MCC-SE model represents a new therapeutic strategy for SCI.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherRoyal Society of Chemistry-
dc.relation.isPartOfBIOMATERIALS SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHCollagen-
dc.subject.MESHEndothelial Cells-
dc.subject.MESHHumans-
dc.subject.MESHNerve Regeneration*-
dc.subject.MESHSchwann Cells-
dc.subject.MESHSpinal Cord-
dc.subject.MESHSpinal Cord Injuries* / therapy-
dc.titleA multi-channel collagen conduit with aligned Schwann cells and endothelial cells for enhanced neuronal regeneration in spinal cord injury-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학교실)-
dc.contributor.googleauthorHye Yeong Lee-
dc.contributor.googleauthorSeo Hyun Moon-
dc.contributor.googleauthorDonggu Kang-
dc.contributor.googleauthorEunjeong Choi-
dc.contributor.googleauthorGi Hoon Yang-
dc.contributor.googleauthorKeung Nyun Kim-
dc.contributor.googleauthorJoo Yun Won-
dc.contributor.googleauthorSeong Yi-
dc.identifier.doi10.1039/d3bm01152f-
dc.contributor.localIdA00331-
dc.contributor.localIdA02864-
dc.contributor.localIdA03317-
dc.relation.journalcodeJ03578-
dc.identifier.eissn2047-4849-
dc.identifier.pmid37906468-
dc.identifier.urlhttps://pubs.rsc.org/en/content/articlelanding/2023/bm/d3bm01152f-
dc.contributor.alternativeNameKim, Keung Nyun-
dc.contributor.affiliatedAuthor김긍년-
dc.contributor.affiliatedAuthor이성-
dc.contributor.affiliatedAuthor이혜영-
dc.citation.volume11-
dc.citation.number24-
dc.citation.startPage7884-
dc.citation.endPage7896-
dc.identifier.bibliographicCitationBIOMATERIALS SCIENCE, Vol.11(24) : 7884-7896, 2023-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.