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Influence of acute kidney injury and its recovery subtypes on patient-centered outcomes after lung transplantation

Authors
 Jin Ha Park  ;  Jae-Kwang Shim  ;  Mingee Choi  ;  Hyun-Soo Zhang  ;  Na Hyung Jun  ;  Seokyeong Choi  ;  Young-Lan Kwak 
Citation
 SCIENTIFIC REPORTS, Vol.14(1) : 10480, 2024-05 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2024-05
MeSH
Acute Kidney Injury* / epidemiology ; Acute Kidney Injury* / etiology ; Adult ; Female ; Humans ; Lung Transplantation* / adverse effects ; Male ; Middle Aged ; Postoperative Complications / epidemiology ; Postoperative Complications / etiology ; Prognosis ; Retrospective Studies
Abstract
This study aimed to investigate the association between acute kidney injury (AKI) recovery subtypes and days alive out of hospital within the first 3 months (DAOH-90) in patients undergoing lung transplantation. Patients who underwent lung transplantation from January 2012 to December 2021 were retrospectively analyzed and stratified into three groups: no-AKI, early recovery AKI (within 7 days), and non-early recovery AKI group. AKI occurred in 86 (35%) of patients, of which 40 (16%) achieved early recovery, and the remaining 46 (19%) did not. The median DAOH-90 was 21 days shorter in the AKI than in the no-AKI (P = 0.002), and 29 days shorter in the non-early recovery AKI group than in the no-AKI group (P < 0.001). Non-early recovery AKI and preoperative tracheostomy status were independently associated with shorter DAOH-90. The prevalence of CKD (76%), and 1-year mortality (48%) were highest in the non-early recovery AKI group. Postoperative AKI was associated with an adverse patient-centered quality measure for perioperative care, and shorter DAOH-90. The non-early recovery AKI group exhibited the worst prognosis in terms of DAOH-90, CKD progression, and 1-year mortality, highlighting the important role of AKI and early-recovery AKI on both the quality of life and clinical outcomes after lung transplantation.
Files in This Item:
T202402901.pdf Download
DOI
10.1038/s41598-024-61352-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
Park, Jin Ha(박진하) ORCID logo https://orcid.org/0000-0002-1398-3304
Shim, Jae Kwang(심재광) ORCID logo https://orcid.org/0000-0001-9093-9692
Choi, Mingee(최민지)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/199251
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