Cited 0 times in
Anti- and pro-fibrillatory effects of pulmonary vein isolation gaps in human atrial fibrillation digital twins
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권오석 | - |
dc.contributor.author | 김대훈 | - |
dc.contributor.author | 김민구 | - |
dc.contributor.author | 김태훈 | - |
dc.contributor.author | 박제욱 | - |
dc.contributor.author | 박희남 | - |
dc.contributor.author | 엄재선 | - |
dc.contributor.author | 유희태 | - |
dc.contributor.author | 이문형 | - |
dc.contributor.author | 정보영 | - |
dc.contributor.author | 진제 | - |
dc.contributor.author | 진제 | - |
dc.contributor.author | 황태현 | - |
dc.contributor.author | 임병현 | - |
dc.contributor.author | 권오석 | - |
dc.contributor.author | 김문현 | - |
dc.date.accessioned | 2024-05-23T03:23:42Z | - |
dc.date.available | 2024-05-23T03:23:42Z | - |
dc.date.issued | 2024-03 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/199218 | - |
dc.description.abstract | Although pulmonary vein isolation (PVI) gaps and extrapulmonary vein triggers contribute to recurrence after atrial fibrillation (AF) ablation, their precise mechanisms remain unproven. Our study assessed the impact of PVI gaps on rhythm outcomes using a human AF digital twin. We included 50 patients (76.0% with persistent AF) who underwent catheter ablation with a realistic AF digital twin by integrating computed tomography and electroanatomical mapping. We evaluated the final rhythm status, including AF and atrial tachycardia (AT), across 600 AF episodes, considering factors including PVI level, PVI gap number, and pacing locations. Our findings revealed that antral PVI had a significantly lower ratio of AF at the final rhythm (28% vs. 56%, p = 0.002) than ostial PVI. Increasing PVI gap numbers correlated with an increased ratio of AF at the final rhythm (p < 0.001). Extra-PV induction yielded a higher ratio of AF at the final rhythm than internal PV induction (77.5% vs. 59.0%, p < 0.001). In conclusion, our human AF digital twin model helped assess AF maintenance mechanisms. Clinical trial registration: https://www.clinicaltrials.gov; Unique identifier: NCT02138695. © The Author(s) 2024. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | NPJ DIGITAL MEDICINE(Nature partner journals digital medicine Digital medicine) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Anti- and pro-fibrillatory effects of pulmonary vein isolation gaps in human atrial fibrillation digital twins | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Ze Jin | - |
dc.contributor.googleauthor | Taehyun Hwang | - |
dc.contributor.googleauthor | Daehoon Kim | - |
dc.contributor.googleauthor | Byounghyun Lim | - |
dc.contributor.googleauthor | Oh-Seok Kwon | - |
dc.contributor.googleauthor | Sangbin Kim | - |
dc.contributor.googleauthor | Moon-Hyun Kim | - |
dc.contributor.googleauthor | Je-Wook Park | - |
dc.contributor.googleauthor | Hee Tae Yu | - |
dc.contributor.googleauthor | Tae-Hoon Kim | - |
dc.contributor.googleauthor | Jae-Sun Uhm | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.contributor.googleauthor | Moon-Hyoung Lee | - |
dc.contributor.googleauthor | Hui-Nam Pak | - |
dc.identifier.doi | 10.1038/s41746-024-01075-y | - |
dc.contributor.localId | A06119 | - |
dc.contributor.localId | A00373 | - |
dc.contributor.localId | A06575 | - |
dc.contributor.localId | A01085 | - |
dc.contributor.localId | A04574 | - |
dc.contributor.localId | A01776 | - |
dc.contributor.localId | A02337 | - |
dc.contributor.localId | A02535 | - |
dc.contributor.localId | A02766 | - |
dc.contributor.localId | A03609 | - |
dc.relation.journalcode | J03796 | - |
dc.identifier.eissn | 2398-6352 | - |
dc.identifier.pmid | 38532181 | - |
dc.contributor.alternativeName | Kwon, Oh-Seok | - |
dc.contributor.affiliatedAuthor | 권오석 | - |
dc.contributor.affiliatedAuthor | 김대훈 | - |
dc.contributor.affiliatedAuthor | 김민구 | - |
dc.contributor.affiliatedAuthor | 김태훈 | - |
dc.contributor.affiliatedAuthor | 박제욱 | - |
dc.contributor.affiliatedAuthor | 박희남 | - |
dc.contributor.affiliatedAuthor | 엄재선 | - |
dc.contributor.affiliatedAuthor | 유희태 | - |
dc.contributor.affiliatedAuthor | 이문형 | - |
dc.contributor.affiliatedAuthor | 정보영 | - |
dc.citation.volume | 7 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 81 | - |
dc.identifier.bibliographicCitation | NPJ DIGITAL MEDICINE(Nature partner journals digital medicine Digital medicine), Vol.7(1) : 81, 2024-03 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.