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The safety and efficacy of intra-arterial low-dose tirofiban administration during endovascular therapy in patients with large ischemic core volume

Authors
 Kwang-Chun Cho  ;  Nak-Hoon Son  ;  So Hyeon Gwon  ;  Jin Wook Choi  ;  Woo Sang Jung 
Citation
 SCIENTIFIC REPORTS, Vol.14(1) : 3353, 2024-02 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2024-02
MeSH
Brain Ischemia* / drug therapy ; Endovascular Procedures* / adverse effects ; Fibrinolytic Agents / therapeutic use ; Humans ; Ischemic Stroke* / etiology ; Stroke* / therapy ; Tirofiban ; Treatment Outcome
Keywords
Acute ischemic stroke ; Alberta Stroke Program Early CT Score ; Endovascular therapy ; Tirofiban
Abstract
This study aimed to evaluate the safety and efficacy of intra-arterial (IA) administration of low- dose tirofiban during endovascular therapy in patients with large ischemic core volumes on initial brain CT. Patients were divided into two groups based on the use of IA tirofiban. We identified 87 patients (16 and 71 patients in the tirofiban and no-tirofiban groups, respectively) with acute ischemic stroke due to intracranial artery occlusion who underwent endovascular therapy with a low Alberta Stroke Program Early CT scores (2–5). Multivariate logistic regression analysis revealed no association between IA tirofiban administration and serious postprocedural hemorrhagic complications (adjusted odds ratio (aOR), 0.720; 95% confidence interval (CI) 0.099–5.219; p = 0.960), any radiologic hemorrhage (aOR 0.076; 95% CI 0.003–2.323; p = 0.139), or 3-month mortality (aOR, 0.087; 95% CI 0.005–1.501; p = 0.093). However, IA tirofiban was associated with a lower 90-day mRS score (aOR, 0.197; 95% CI 0.015–1.306; p = 0.017) and change of NIHSS compared with baseline (aOR, 0.698; 95% CI 0.531–0.917; p = 0.010). IA tirofiban administration during endovascular therapy in patients with large ischemic core volumes may be effective and safe. © The Author(s) 2024.
Files in This Item:
T202402752.pdf Download
DOI
10.1038/s41598-024-53715-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Cho, Kwang Chun(조광천) ORCID logo https://orcid.org/0000-0002-0261-9283
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/199217
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